Hydrogen sulfide (H2S) is gaining interest as a mammalian signalling molecule with wide ranging effects. S-sulfhydration is one mechanism that is emerging as a key post translational modification through which H2S acts. Ion channels and neuronal receptors are key target proteins for S-sulfhydration and this can influence a range of neuronal functions. Voltage-gated K+ channels, including Kv2.1, are fundamental components of neuronal excitability.

Reference
Pubmed: Dallas ML, Al-Owais MM, Hettiarachchi NT, Vandiver MS, Jarosz-Griffiths HH, Scragg JL, Boyle JP, Steele D, Peers C. Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1. Sci Rep. 2021 Apr 14;11(1):8194. doi: 10.1038/s41598-021-87646-5.