PTMD 2.0 (PTMs that are associated with human Disease) is a manually curated database that contains the associations between different PTM types and different diseases. Currently, PTMD contains 342,624 PTM-disease associations (PDAs), 15,105 proteins for 93 PTM types and 2,083 diseases. To better view the PTM and disease, we classify the associations into 6 groups, including U/D (Up/Down), P/A (Present/Absent) and C/N (Mutation induce PTM/Mutation remove PTM), respectively.
    Here we provide three approaches for users to browse the database: (i) By PDAs; (ii) By Diseases ; (iii) By PTMs. PTMs browse allows users to select an interested post translational modification type and the proteins which have relationship of this PTM and diseases will be presented after clicking the link. When browsing by diseases, users can choose a specific disease type and get the proteins whose PTMs are involved in this disease. The annotation information of each protein will be presented in the final webpage.

※ Browse by PDAs

The PTMD 2.0 classifies 342, 624 PTM–disease associations (PDAs) into 6 types based on the PTM status in diseases.

※ Browse by Diseases

The PTMD 2.0 arranges 2,083 diseases into 34 super-types based on tissue location.

※ Browse by PTMs

The PTMD 2.0 arranges post-translational modifications (PTMs) into 49 super-types based on modification type.