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Browse result for Down-regulation in Gamma-carboxylation
※ introduction Carboxyglutamic acid (or the conjugate base, carboxyglutamate), is an uncommon amino acid introduced into proteins by a post-translational carboxylation of glutamic acid residues. This modification is found, for example, in clotting factors and other proteins of the coagulation cascade. This modification introduces an affinity for calcium ions. In the blood coagulation cascade, vitamin K is required to introduce ¦Ã-carboxylation of clotting factors II, VII, IX, X and protein Z.
Reference
Wiki: Gamma-carboxylation
Reference
Wiki: Gamma-carboxylation
| PTMD ID | UniProt Accession | Entrez ID | Gene Name | Protein Name | Organism |
|---|---|---|---|---|---|
| PTMD00980 | P02818 | 632 | BGLAP | Osteocalcin | Homo sapiens |
| PTMD00981 | P00734 | 2147 | F2 | Prothrombin [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] | Homo sapiens |
| PTMD00982 | Q8WVF2 | 22104 | UCMA | Unique cartilage matrix-associated protein [Cleaved into: Unique cartilage matrix-associated protein C-terminal fragment ] | Homo sapiens |
| PTMD01384 | P08493 | 4256 | MGP | Matrix Gla protein | Homo sapiens |
