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Browse result for Skin cancer

※ introduction

    Skin cancers are cancers that arise from the skin. They are due to the development of abnormal cells that have the ability to invade or spread to other parts of the body. Skin cancer is the most commonly diagnosed form of cancer in humans. There are three main types of skin cancers: basal-cell skin cancer (BCC), squamous-cell skin cancer (SCC) and melanoma. The first two, along with a number of less common skin cancers, are known as nonmelanoma skin cancer (NMSC). Basal-cell cancer grows slowly and can damage the tissue around it but is unlikely to spread to distant areas or result in death. It often appears as a painless raised area of skin that may be shiny with small blood vessels running over it or may present as a raised area with an ulcer. Squamous-cell skin cancer is more likely to spread. It usually presents as a hard lump with a scaly top but may also form an ulcer. Melanomas are the most aggressive. Signs include a mole that has changed in size, shape, color, has irregular edges, has more than one color, is itchy or bleeds. More than 90% of cases are caused by exposure to ultraviolet radiation from the Sun. This exposure increases the risk of all three main types of skin cancer. Exposure has increased, partly due to a thinner ozone layer. Tanning beds are another common source of ultraviolet radiation. For melanomas and basal-cell cancers, exposure during childhood is particularly harmful. For squamous-cell skin cancers, total exposure, irrespective of when it occurs, is more important. Between 20% and 30% of melanomas develop from moles. People with lighter skin are at higher risk as are those with poor immune function such as from medications or HIV/AIDS. Diagnosis is by biopsy. Decreasing exposure to ultraviolet radiation and the use of sunscreen appear to be effective methods of preventing melanoma and squamous-cell skin cancer. It is not clear if sunscreen affects the risk of basal-cell cancer. Nonmelanoma skin cancer is usually curable. Treatment is generally by surgical removal but may, less commonly, involve radiation therapy or topical medications such as fluorouracil. Treatment of melanoma may involve some combination of surgery, chemotherapy, radiation therapy and targeted therapy. In those people whose disease has spread to other areas of the body, palliative care may be used to improve quality of life. Melanoma has one of the higher survival rates among cancers, with over 86% of people in the UK and more than 90% in the United States surviving more than 5 years. Skin cancer is the most common form of cancer, globally accounting for at least 40% of cancer cases. The most common type is nonmelanoma skin cancer, which occurs in at least 2¨C3 million people per year. This is a rough estimate, however, as good statistics are not kept. Of nonmelanoma skin cancers, about 80% are basal-cell cancers and 20% squamous-cell skin cancers. Basal-cell and squamous-cell skin cancers rarely result in death. In the United States, they were the cause of less than 0.1% of all cancer deaths. Globally in 2012, melanoma occurred in 232,000 people and resulted in 55,000 deaths. White people in Australia, New Zealand and South Africa have the highest rates of melanoma in the world. The three main types of skin cancer have become more common in the last 20 to 40 years, especially regions where the population is predominantly White.

Reference
Wiki: Skin cancer



PTMD IDUniProt AccessionEntrez IDGene NameProtein NameOrganism
PTMD00258O149203551
IKBKB
Inhibitor of nuclear factor kappa-B kinase subunit beta
Homo sapiens
PTMD01051P00352216
ALDH1A1
Aldehyde dehydrogenase 1A1
Homo sapiens
PTMD01052P0051925
ABL1
Tyrosine-protein kinase ABL1
Homo sapiens
PTMD00540P149233728
JUP
Junction plakoglobin
Homo sapiens
PTMD00153Q1416023513
SCRIB
Protein scribble homolog
Homo sapiens
PTMD00427Q8IY3379778
MICALL2
MICAL-like protein 2
Homo sapiens
PTMD00091Q96EB623411
SIRT1
NAD-dependent protein deacetylase sirtuin-1 [Cleaved into: SirtT1 75 kDa fragment ]
Homo sapiens
PTMD00030Q96FF911313
CDCA5
Sororin
Homo sapiens
PTMD00779Q96RK023152
CIC
Protein capicua homolog
Homo sapiens
PTMD01019Q9NPD528234
SLCO1B3
Solute carrier organic anion transporter family member 1B3
Homo sapiens
PTMD00805Q9NQS73619
INCENP
Inner centromere protein
Homo sapiens
PTMD00075P064005925
RB1
Retinoblastoma-associated protein
Homo sapiens
PTMD00040P407636774
STAT3
Signal transducer and activator of transcription 3
Homo sapiens
PTMD00041P498412932
GSK3B
Glycogen synthase kinase-3 beta
Homo sapiens
PTMD00210Q053975747
PTK2
Focal adhesion kinase 1
Homo sapiens
PTMD00662Q068305052
PRDX1
Peroxiredoxin-1
Homo sapiens
PTMD02128A6NNZ2
TUBB8B
Tubulin beta 8B
Homo sapiens
PTMD01409O144978289
ARID1A
AT-rich interactive domain-containing protein 1A
Homo sapiens
PTMD01582P295905371
PML
Protein PML
Homo sapiens
PTMD01596P325191997
ELF1
ETS-related transcription factor Elf-1
Homo sapiens
PTMD01706P785594130
MAP1A
Microtubule-associated protein 1A [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2]
Homo sapiens
PTMD01751Q145246331
SCN5A
Sodium channel protein type 5 subunit alpha
Homo sapiens
PTMD01773Q166586624
FSCN1
Fascin
Homo sapiens
PTMD02272O0026410857
PGRMC1
Membrane-associated progesterone receptor component 1
Homo sapiens
PTMD02727O435819066
SYT7
Synaptotagmin-7
Homo sapiens
PTMD03292O9485023109
DDN
Dendrin
Homo sapiens
PTMD03322O9492922885
ABLIM3
Actin-binding LIM protein 3
Homo sapiens
PTMD03371O951718796
SCEL
Sciellin
Homo sapiens
PTMD03782P059971290
COL5A2
Collagen alpha-2 chain
Homo sapiens
PTMD04009P0DPB551082
POLR1D
Protein POLR1D, isoform 2
Homo sapiens
PTMD04527P226072261
FGFR3
Fibroblast growth factor receptor 3
Homo sapiens
PTMD04650P2636811338
U2AF2
Splicing factor U2AF 65 kDa subunit )
Homo sapiens
PTMD04894P349472869
GRK5
G protein-coupled receptor kinase 5
Homo sapiens
PTMD05183P467776125
RPL5
Large ribosomal subunit protein uL18
Homo sapiens
PTMD05196P477101446
CSN1S1
Alpha-S1-casein [Cleaved into: Casoxin-D]
Homo sapiens
PTMD05461P517981186
CLCN7
H/Cl exchange transporter 7
Homo sapiens
PTMD05663P561924141
MARS1
Methionine--tRNA ligase, cytoplasmic
Homo sapiens
PTMD05933P783128603
FAM193A
Protein FAM193A
Homo sapiens
PTMD06136Q020408227
AKAP17A
A-kinase anchor protein 17A
Homo sapiens
PTMD06185Q031881060
CENPC
Centromere protein C
Homo sapiens
PTMD06875Q150209733
SART3
Squamous cell carcinoma antigen recognized by T-cells 3
Homo sapiens
PTMD06914Q151495339
PLEC
Plectin
Homo sapiens
PTMD06970Q1545910291
SF3A1
Splicing factor 3A subunit 1
Homo sapiens
PTMD07020Q1573527124
INPP5J
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
Homo sapiens
PTMD07051Q15878777
CACNA1E
Voltage-dependent R-type calcium channel subunit alpha-1E
Homo sapiens
PTMD07065Q161342110
ETFDH
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
Homo sapiens
PTMD07242Q2M3C780309
SPHKAP
A-kinase anchor protein SPHKAP
Homo sapiens
PTMD07298Q32MZ49208
LRRFIP1
Leucine-rich repeat flightless-interacting protein 1
Homo sapiens
PTMD07421Q4V32856850
GRIPAP1
GRIP1-associated protein 1 [Cleaved into: GRASP-1 C-terminal chain ]
Homo sapiens
PTMD07444Q52LW39411
ARHGAP29
Rho GTPase-activating protein 29
Homo sapiens
PTMD07677Q5SRE523511
NUP188
Nucleoporin NUP188
Homo sapiens
PTMD07853Q5VST984033
OBSCN
Obscurin
Homo sapiens
PTMD07873Q5VUA424149
ZNF318
Zinc finger protein 318
Homo sapiens
PTMD07983Q684P523108
RAP1GAP2
Rap1 GTPase-activating protein 2
Homo sapiens
PTMD08122Q6IQ2623258
DENND5A
DENN domain-containing protein 5A
Homo sapiens
PTMD08470Q6VY0755690
PACS1
Phosphofurin acidic cluster sorting protein 1
Homo sapiens
PTMD08471Q6W2J954880
BCOR
BCL-6 corepressor
Homo sapiens
PTMD08660Q75QN255656
INTS8
Integrator complex subunit 8
Homo sapiens
PTMD08908Q7Z79437445
KRT77
Keratin, type II cytoskeletal 1b
Homo sapiens
PTMD09115Q86WR725442
PROSER2
Proline and serine-rich protein 2
Homo sapiens
PTMD09216Q8IU8126145
IRF2BP1
Interferon regulatory factor 2-binding protein 1
Homo sapiens
PTMD09352Q8IWY914605
CDAN1
Codanin-1
Homo sapiens
PTMD09361Q8IX0716188
ZFPM1
Zinc finger protein ZFPM1
Homo sapiens
PTMD09620Q8N30255109
AGGF1
Angiogenic factor with G patch and FHA domains 1
Homo sapiens
PTMD09676Q8N4B528580
PRR18
Proline-rich protein 18
Homo sapiens
PTMD09961Q8NC9625977
NECAP1
Adaptin ear-binding coat-associated protein 1
Homo sapiens
PTMD10032Q8NE3122096
FAM13C
Protein FAM13C
Homo sapiens
PTMD10191Q8NHM584678
KDM2B
Lysine-specific demethylase 2B
Homo sapiens
PTMD10322Q8TC7113267
SPATA18
Mitochondria-eating protein
Homo sapiens
PTMD10468Q8TF4284959
UBASH3B
Ubiquitin-associated and SH3 domain-containing protein B
Homo sapiens
PTMD10508Q8WUA42976
GTF3C2
General transcription factor 3C polypeptide 2
Homo sapiens
PTMD10645Q8WXD957524
CASKIN1
Caskin-1
Homo sapiens
PTMD11446Q96KQ710919
EHMT2
Histone-lysine N-methyltransferase EHMT2
Homo sapiens
PTMD11858Q996409088
PKMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Homo sapiens
PTMD11973Q9BQF657337
SENP7
Sentrin-specific protease 7
Homo sapiens
PTMD12291Q9BXK523786
BCL2L13
Bcl-2-like protein 13
Homo sapiens
PTMD12567Q9H0A984221
SPATC1L
Speriolin-like protein
Homo sapiens
PTMD12905Q9H7N458506
SCAF1
Splicing factor, arginine/serine-rich 19
Homo sapiens
PTMD13260Q9NQ2955692
LUC7L
Putative RNA-binding protein Luc7-like 1
Homo sapiens
PTMD13269Q9NQ6623236
PLCB1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Homo sapiens
PTMD13421Q9NS4090134
KCNH7
Potassium voltage-gated channel subfamily H member 7
Homo sapiens
PTMD13588Q9NWB154715
RBFOX1
RNA binding protein fox-1 homolog 1
Homo sapiens
PTMD13674Q9NXN454834
GDAP2
Ganglioside-induced differentiation-associated protein 2
Homo sapiens
PTMD13762Q9NZ7250861
STMN3
Stathmin-3
Homo sapiens
PTMD13948Q9P2K844027
EIF2AK4
eIF-2-alpha kinase GCN2
Homo sapiens
PTMD14680Q9Y2K522864
R3HDM2
R3H domain-containing protein 2
Homo sapiens
PTMD15011Q9Y6234622
MYH4
Myosin-4
Homo sapiens