※ PTMD 2.0 database Online Browse Options
Browse result for Skin cancer
※ introduction Skin cancers are cancers that arise from the skin. They are due to the development of abnormal cells that have the ability to invade or spread to other parts of the body. Skin cancer is the most commonly diagnosed form of cancer in humans. There are three main types of skin cancers: basal-cell skin cancer (BCC), squamous-cell skin cancer (SCC) and melanoma. The first two, along with a number of less common skin cancers, are known as nonmelanoma skin cancer (NMSC). Basal-cell cancer grows slowly and can damage the tissue around it but is unlikely to spread to distant areas or result in death. It often appears as a painless raised area of skin that may be shiny with small blood vessels running over it or may present as a raised area with an ulcer. Squamous-cell skin cancer is more likely to spread. It usually presents as a hard lump with a scaly top but may also form an ulcer. Melanomas are the most aggressive. Signs include a mole that has changed in size, shape, color, has irregular edges, has more than one color, is itchy or bleeds.
More than 90% of cases are caused by exposure to ultraviolet radiation from the Sun. This exposure increases the risk of all three main types of skin cancer. Exposure has increased, partly due to a thinner ozone layer. Tanning beds are another common source of ultraviolet radiation. For melanomas and basal-cell cancers, exposure during childhood is particularly harmful. For squamous-cell skin cancers, total exposure, irrespective of when it occurs, is more important. Between 20% and 30% of melanomas develop from moles. People with lighter skin are at higher risk as are those with poor immune function such as from medications or HIV/AIDS. Diagnosis is by biopsy.
Decreasing exposure to ultraviolet radiation and the use of sunscreen appear to be effective methods of preventing melanoma and squamous-cell skin cancer. It is not clear if sunscreen affects the risk of basal-cell cancer. Nonmelanoma skin cancer is usually curable. Treatment is generally by surgical removal but may, less commonly, involve radiation therapy or topical medications such as fluorouracil. Treatment of melanoma may involve some combination of surgery, chemotherapy, radiation therapy and targeted therapy. In those people whose disease has spread to other areas of the body, palliative care may be used to improve quality of life. Melanoma has one of the higher survival rates among cancers, with over 86% of people in the UK and more than 90% in the United States surviving more than 5 years.
Skin cancer is the most common form of cancer, globally accounting for at least 40% of cancer cases. The most common type is nonmelanoma skin cancer, which occurs in at least 2¨C3 million people per year. This is a rough estimate, however, as good statistics are not kept. Of nonmelanoma skin cancers, about 80% are basal-cell cancers and 20% squamous-cell skin cancers. Basal-cell and squamous-cell skin cancers rarely result in death. In the United States, they were the cause of less than 0.1% of all cancer deaths. Globally in 2012, melanoma occurred in 232,000 people and resulted in 55,000 deaths. White people in Australia, New Zealand and South Africa have the highest rates of melanoma in the world. The three main types of skin cancer have become more common in the last 20 to 40 years, especially regions where the population is predominantly White.
Reference
Wiki: Skin cancer
Reference
Wiki: Skin cancer
| PTMD ID | UniProt Accession | Entrez ID | Gene Name | Protein Name | Organism |
|---|---|---|---|---|---|
| PTMD00258 | O14920 | 3551 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens |
| PTMD01051 | P00352 | 216 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Homo sapiens |
| PTMD01052 | P00519 | 25 | ABL1 | Tyrosine-protein kinase ABL1 | Homo sapiens |
| PTMD00540 | P14923 | 3728 | JUP | Junction plakoglobin | Homo sapiens |
| PTMD00153 | Q14160 | 23513 | SCRIB | Protein scribble homolog | Homo sapiens |
| PTMD00427 | Q8IY33 | 79778 | MICALL2 | MICAL-like protein 2 | Homo sapiens |
| PTMD00091 | Q96EB6 | 23411 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 [Cleaved into: SirtT1 75 kDa fragment ] | Homo sapiens |
| PTMD00030 | Q96FF9 | 11313 | CDCA5 | Sororin | Homo sapiens |
| PTMD00779 | Q96RK0 | 23152 | CIC | Protein capicua homolog | Homo sapiens |
| PTMD01019 | Q9NPD5 | 28234 | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Homo sapiens |
| PTMD00805 | Q9NQS7 | 3619 | INCENP | Inner centromere protein | Homo sapiens |
| PTMD00075 | P06400 | 5925 | RB1 | Retinoblastoma-associated protein | Homo sapiens |
| PTMD00040 | P40763 | 6774 | STAT3 | Signal transducer and activator of transcription 3 | Homo sapiens |
| PTMD00041 | P49841 | 2932 | GSK3B | Glycogen synthase kinase-3 beta | Homo sapiens |
| PTMD00210 | Q05397 | 5747 | PTK2 | Focal adhesion kinase 1 | Homo sapiens |
| PTMD00662 | Q06830 | 5052 | PRDX1 | Peroxiredoxin-1 | Homo sapiens |
| PTMD02128 | A6NNZ2 | TUBB8B | Tubulin beta 8B | Homo sapiens | |
| PTMD01409 | O14497 | 8289 | ARID1A | AT-rich interactive domain-containing protein 1A | Homo sapiens |
| PTMD01582 | P29590 | 5371 | PML | Protein PML | Homo sapiens |
| PTMD01596 | P32519 | 1997 | ELF1 | ETS-related transcription factor Elf-1 | Homo sapiens |
| PTMD01706 | P78559 | 4130 | MAP1A | Microtubule-associated protein 1A [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Homo sapiens |
| PTMD01751 | Q14524 | 6331 | SCN5A | Sodium channel protein type 5 subunit alpha | Homo sapiens |
| PTMD01773 | Q16658 | 6624 | FSCN1 | Fascin | Homo sapiens |
| PTMD02272 | O00264 | 10857 | PGRMC1 | Membrane-associated progesterone receptor component 1 | Homo sapiens |
| PTMD02727 | O43581 | 9066 | SYT7 | Synaptotagmin-7 | Homo sapiens |
| PTMD03292 | O94850 | 23109 | DDN | Dendrin | Homo sapiens |
| PTMD03322 | O94929 | 22885 | ABLIM3 | Actin-binding LIM protein 3 | Homo sapiens |
| PTMD03371 | O95171 | 8796 | SCEL | Sciellin | Homo sapiens |
| PTMD03782 | P05997 | 1290 | COL5A2 | Collagen alpha-2 chain | Homo sapiens |
| PTMD04009 | P0DPB5 | 51082 | POLR1D | Protein POLR1D, isoform 2 | Homo sapiens |
| PTMD04527 | P22607 | 2261 | FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens |
| PTMD04650 | P26368 | 11338 | U2AF2 | Splicing factor U2AF 65 kDa subunit ) | Homo sapiens |
| PTMD04894 | P34947 | 2869 | GRK5 | G protein-coupled receptor kinase 5 | Homo sapiens |
| PTMD05183 | P46777 | 6125 | RPL5 | Large ribosomal subunit protein uL18 | Homo sapiens |
| PTMD05196 | P47710 | 1446 | CSN1S1 | Alpha-S1-casein [Cleaved into: Casoxin-D] | Homo sapiens |
| PTMD05461 | P51798 | 1186 | CLCN7 | H/Cl exchange transporter 7 | Homo sapiens |
| PTMD05663 | P56192 | 4141 | MARS1 | Methionine--tRNA ligase, cytoplasmic | Homo sapiens |
| PTMD05933 | P78312 | 8603 | FAM193A | Protein FAM193A | Homo sapiens |
| PTMD06136 | Q02040 | 8227 | AKAP17A | A-kinase anchor protein 17A | Homo sapiens |
| PTMD06185 | Q03188 | 1060 | CENPC | Centromere protein C | Homo sapiens |
| PTMD06875 | Q15020 | 9733 | SART3 | Squamous cell carcinoma antigen recognized by T-cells 3 | Homo sapiens |
| PTMD06914 | Q15149 | 5339 | PLEC | Plectin | Homo sapiens |
| PTMD06970 | Q15459 | 10291 | SF3A1 | Splicing factor 3A subunit 1 | Homo sapiens |
| PTMD07020 | Q15735 | 27124 | INPP5J | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A | Homo sapiens |
| PTMD07051 | Q15878 | 777 | CACNA1E | Voltage-dependent R-type calcium channel subunit alpha-1E | Homo sapiens |
| PTMD07065 | Q16134 | 2110 | ETFDH | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | Homo sapiens |
| PTMD07242 | Q2M3C7 | 80309 | SPHKAP | A-kinase anchor protein SPHKAP | Homo sapiens |
| PTMD07298 | Q32MZ4 | 9208 | LRRFIP1 | Leucine-rich repeat flightless-interacting protein 1 | Homo sapiens |
| PTMD07421 | Q4V328 | 56850 | GRIPAP1 | GRIP1-associated protein 1 [Cleaved into: GRASP-1 C-terminal chain ] | Homo sapiens |
| PTMD07444 | Q52LW3 | 9411 | ARHGAP29 | Rho GTPase-activating protein 29 | Homo sapiens |
| PTMD07677 | Q5SRE5 | 23511 | NUP188 | Nucleoporin NUP188 | Homo sapiens |
| PTMD07853 | Q5VST9 | 84033 | OBSCN | Obscurin | Homo sapiens |
| PTMD07873 | Q5VUA4 | 24149 | ZNF318 | Zinc finger protein 318 | Homo sapiens |
| PTMD07983 | Q684P5 | 23108 | RAP1GAP2 | Rap1 GTPase-activating protein 2 | Homo sapiens |
| PTMD08122 | Q6IQ26 | 23258 | DENND5A | DENN domain-containing protein 5A | Homo sapiens |
| PTMD08470 | Q6VY07 | 55690 | PACS1 | Phosphofurin acidic cluster sorting protein 1 | Homo sapiens |
| PTMD08471 | Q6W2J9 | 54880 | BCOR | BCL-6 corepressor | Homo sapiens |
| PTMD08660 | Q75QN2 | 55656 | INTS8 | Integrator complex subunit 8 | Homo sapiens |
| PTMD08908 | Q7Z794 | 37445 | KRT77 | Keratin, type II cytoskeletal 1b | Homo sapiens |
| PTMD09115 | Q86WR7 | 25442 | PROSER2 | Proline and serine-rich protein 2 | Homo sapiens |
| PTMD09216 | Q8IU81 | 26145 | IRF2BP1 | Interferon regulatory factor 2-binding protein 1 | Homo sapiens |
| PTMD09352 | Q8IWY9 | 14605 | CDAN1 | Codanin-1 | Homo sapiens |
| PTMD09361 | Q8IX07 | 16188 | ZFPM1 | Zinc finger protein ZFPM1 | Homo sapiens |
| PTMD09620 | Q8N302 | 55109 | AGGF1 | Angiogenic factor with G patch and FHA domains 1 | Homo sapiens |
| PTMD09676 | Q8N4B5 | 28580 | PRR18 | Proline-rich protein 18 | Homo sapiens |
| PTMD09961 | Q8NC96 | 25977 | NECAP1 | Adaptin ear-binding coat-associated protein 1 | Homo sapiens |
| PTMD10032 | Q8NE31 | 22096 | FAM13C | Protein FAM13C | Homo sapiens |
| PTMD10191 | Q8NHM5 | 84678 | KDM2B | Lysine-specific demethylase 2B | Homo sapiens |
| PTMD10322 | Q8TC71 | 13267 | SPATA18 | Mitochondria-eating protein | Homo sapiens |
| PTMD10468 | Q8TF42 | 84959 | UBASH3B | Ubiquitin-associated and SH3 domain-containing protein B | Homo sapiens |
| PTMD10508 | Q8WUA4 | 2976 | GTF3C2 | General transcription factor 3C polypeptide 2 | Homo sapiens |
| PTMD10645 | Q8WXD9 | 57524 | CASKIN1 | Caskin-1 | Homo sapiens |
| PTMD11446 | Q96KQ7 | 10919 | EHMT2 | Histone-lysine N-methyltransferase EHMT2 | Homo sapiens |
| PTMD11858 | Q99640 | 9088 | PKMYT1 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | Homo sapiens |
| PTMD11973 | Q9BQF6 | 57337 | SENP7 | Sentrin-specific protease 7 | Homo sapiens |
| PTMD12291 | Q9BXK5 | 23786 | BCL2L13 | Bcl-2-like protein 13 | Homo sapiens |
| PTMD12567 | Q9H0A9 | 84221 | SPATC1L | Speriolin-like protein | Homo sapiens |
| PTMD12905 | Q9H7N4 | 58506 | SCAF1 | Splicing factor, arginine/serine-rich 19 | Homo sapiens |
| PTMD13260 | Q9NQ29 | 55692 | LUC7L | Putative RNA-binding protein Luc7-like 1 | Homo sapiens |
| PTMD13269 | Q9NQ66 | 23236 | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | Homo sapiens |
| PTMD13421 | Q9NS40 | 90134 | KCNH7 | Potassium voltage-gated channel subfamily H member 7 | Homo sapiens |
| PTMD13588 | Q9NWB1 | 54715 | RBFOX1 | RNA binding protein fox-1 homolog 1 | Homo sapiens |
| PTMD13674 | Q9NXN4 | 54834 | GDAP2 | Ganglioside-induced differentiation-associated protein 2 | Homo sapiens |
| PTMD13762 | Q9NZ72 | 50861 | STMN3 | Stathmin-3 | Homo sapiens |
| PTMD13948 | Q9P2K8 | 44027 | EIF2AK4 | eIF-2-alpha kinase GCN2 | Homo sapiens |
| PTMD14680 | Q9Y2K5 | 22864 | R3HDM2 | R3H domain-containing protein 2 | Homo sapiens |
| PTMD15011 | Q9Y623 | 4622 | MYH4 | Myosin-4 | Homo sapiens |
