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Browse result for Primary dilated cardiomyopathy

※ introduction

    Dilated cardiomyopathy (DCM) is a condition in which the heart becomes enlarged and cannot pump blood effectively. Symptoms vary from none to feeling tired, leg swelling, and shortness of breath. It may also result in chest pain or fainting. Complications can include heart failure, heart valve disease, or an irregular heartbeat. Causes include genetics, alcohol, cocaine, certain toxins, complications of pregnancy, and certain infections. Coronary artery disease and high blood pressure may play a role, but are not the primary cause. In many cases the cause remains unclear. It is a type of cardiomyopathy, a group of diseases that primarily affects the heart muscle. The diagnosis may be supported by an electrocardiogram, chest X-ray, or echocardiogram. In those with heart failure, treatment may include medications in the ACE inhibitor, beta blocker, and diuretic families. A low salt diet may also be helpful. In those with certain types of irregular heartbeat, blood thinners or an implantable cardioverter defibrillator may be recommended. Cardiac resynchronization therapy (CRT) may be necessary. If other measures are not effective a heart transplant may be an option in some. About 1 per 2,500 people is affected. It occurs more frequently in men than women. Onset is most often in middle age. Five-year survival rate is about 50%. It can also occur in children and is the most common type of cardiomyopathy in this age group.

Reference
Wiki: Primary dilated cardiomyopathy



PTMD IDUniProt AccessionEntrez IDGene NameProtein NameOrganism
PTMD01049O958179531
BAG3
BAG family molecular chaperone regulator 3
Homo sapiens
PTMD00500P025454000
LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C ]
Homo sapiens
PTMD02221E7EWK110587
TXNRD2
Thioredoxin reductase 2
Homo sapiens
PTMD01461P025111410
CRYAB
Alpha-crystallin B chain -crystallin)
Homo sapiens
PTMD01064P094937168
TPM1
Tropomyosin alpha-1 chain
Homo sapiens
PTMD01525P159241832
DSP
Desmoplakin
Homo sapiens
PTMD01536P176611674
DES
Desmin
Homo sapiens
PTMD01627P453797139
TNNT2
Troponin T, cardiac muscle
Homo sapiens
PTMD01643P498402931
GSK3A
Glycogen synthase kinase-3 alpha
Homo sapiens
PTMD01694P6803270
ACTC1
Actin, alpha cardiac muscle 1 [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Homo sapiens
PTMD01751Q145246331
SCN5A
Sodium channel protein type 5 subunit alpha
Homo sapiens
PTMD01131Q148964607
MYBPC3
Myosin-binding protein C, cardiac-type
Homo sapiens
PTMD03247O7604110529
NEBL
Nebulette
Homo sapiens
PTMD03853P079517169
TPM2
Tropomyosin beta chain
Homo sapiens
PTMD04088P115321756
DMD
Dystrophin
Homo sapiens
PTMD04130P128834625
MYH7
Myosin-7
Homo sapiens
PTMD04145P135334624
MYH6
Myosin-6
Homo sapiens
PTMD05083P421667112
TMPO
Lamina-associated polypeptide 2, isoform alpha [Cleaved into: Thymopoietin ; Thymopentin ]
Homo sapiens
PTMD05377P504022010
EMD
Emerin
Homo sapiens
PTMD06532Q134183611
ILK
Integrin-linked protein kinase
Homo sapiens
PTMD06676Q141261829
DSG2
Desmoglein-2
Homo sapiens
PTMD06704Q141922274
FHL2
Four and a half LIM domains protein 2
Homo sapiens
PTMD06724Q143152318
FLNC
Filamin-C
Homo sapiens
PTMD06937Q1532727063
ANKRD1
Ankyrin repeat domain-containing protein 1
Homo sapiens
PTMD07462Q53GG527295
PDLIM3
PDZ and LIM domain protein 3
Homo sapiens
PTMD07741Q5T48128299
RBM20
RNA-binding protein 20
Homo sapiens
PTMD09336Q8IWT16330
SCN4B
Sodium channel subunit beta-4
Homo sapiens
PTMD11648Q96PU523327
NEDD4L
E3 ubiquitin-protein ligase NEDD4-like
Homo sapiens
PTMD12114Q9BTV479188
TMEM43
Transmembrane protein 43
Homo sapiens