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Browse result for Primary dilated cardiomyopathy
※ introduction Dilated cardiomyopathy (DCM) is a condition in which the heart becomes enlarged and cannot pump blood effectively. Symptoms vary from none to feeling tired, leg swelling, and shortness of breath. It may also result in chest pain or fainting. Complications can include heart failure, heart valve disease, or an irregular heartbeat.
Causes include genetics, alcohol, cocaine, certain toxins, complications of pregnancy, and certain infections. Coronary artery disease and high blood pressure may play a role, but are not the primary cause. In many cases the cause remains unclear. It is a type of cardiomyopathy, a group of diseases that primarily affects the heart muscle. The diagnosis may be supported by an electrocardiogram, chest X-ray, or echocardiogram.
In those with heart failure, treatment may include medications in the ACE inhibitor, beta blocker, and diuretic families. A low salt diet may also be helpful. In those with certain types of irregular heartbeat, blood thinners or an implantable cardioverter defibrillator may be recommended. Cardiac resynchronization therapy (CRT) may be necessary. If other measures are not effective a heart transplant may be an option in some.
About 1 per 2,500 people is affected. It occurs more frequently in men than women. Onset is most often in middle age. Five-year survival rate is about 50%. It can also occur in children and is the most common type of cardiomyopathy in this age group.
Reference
Wiki: Primary dilated cardiomyopathy
Reference
Wiki: Primary dilated cardiomyopathy
| PTMD ID | UniProt Accession | Entrez ID | Gene Name | Protein Name | Organism |
|---|---|---|---|---|---|
| PTMD01049 | O95817 | 9531 | BAG3 | BAG family molecular chaperone regulator 3 | Homo sapiens |
| PTMD00500 | P02545 | 4000 | LMNA | Prelamin-A/C [Cleaved into: Lamin-A/C ] | Homo sapiens |
| PTMD02221 | E7EWK1 | 10587 | TXNRD2 | Thioredoxin reductase 2 | Homo sapiens |
| PTMD01461 | P02511 | 1410 | CRYAB | Alpha-crystallin B chain -crystallin) | Homo sapiens |
| PTMD01064 | P09493 | 7168 | TPM1 | Tropomyosin alpha-1 chain | Homo sapiens |
| PTMD01525 | P15924 | 1832 | DSP | Desmoplakin | Homo sapiens |
| PTMD01536 | P17661 | 1674 | DES | Desmin | Homo sapiens |
| PTMD01627 | P45379 | 7139 | TNNT2 | Troponin T, cardiac muscle | Homo sapiens |
| PTMD01643 | P49840 | 2931 | GSK3A | Glycogen synthase kinase-3 alpha | Homo sapiens |
| PTMD01694 | P68032 | 70 | ACTC1 | Actin, alpha cardiac muscle 1 [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Homo sapiens |
| PTMD01751 | Q14524 | 6331 | SCN5A | Sodium channel protein type 5 subunit alpha | Homo sapiens |
| PTMD01131 | Q14896 | 4607 | MYBPC3 | Myosin-binding protein C, cardiac-type | Homo sapiens |
| PTMD03247 | O76041 | 10529 | NEBL | Nebulette | Homo sapiens |
| PTMD03853 | P07951 | 7169 | TPM2 | Tropomyosin beta chain | Homo sapiens |
| PTMD04088 | P11532 | 1756 | DMD | Dystrophin | Homo sapiens |
| PTMD04130 | P12883 | 4625 | MYH7 | Myosin-7 | Homo sapiens |
| PTMD04145 | P13533 | 4624 | MYH6 | Myosin-6 | Homo sapiens |
| PTMD05083 | P42166 | 7112 | TMPO | Lamina-associated polypeptide 2, isoform alpha [Cleaved into: Thymopoietin ; Thymopentin ] | Homo sapiens |
| PTMD05377 | P50402 | 2010 | EMD | Emerin | Homo sapiens |
| PTMD06532 | Q13418 | 3611 | ILK | Integrin-linked protein kinase | Homo sapiens |
| PTMD06676 | Q14126 | 1829 | DSG2 | Desmoglein-2 | Homo sapiens |
| PTMD06704 | Q14192 | 2274 | FHL2 | Four and a half LIM domains protein 2 | Homo sapiens |
| PTMD06724 | Q14315 | 2318 | FLNC | Filamin-C | Homo sapiens |
| PTMD06937 | Q15327 | 27063 | ANKRD1 | Ankyrin repeat domain-containing protein 1 | Homo sapiens |
| PTMD07462 | Q53GG5 | 27295 | PDLIM3 | PDZ and LIM domain protein 3 | Homo sapiens |
| PTMD07741 | Q5T481 | 28299 | RBM20 | RNA-binding protein 20 | Homo sapiens |
| PTMD09336 | Q8IWT1 | 6330 | SCN4B | Sodium channel subunit beta-4 | Homo sapiens |
| PTMD11648 | Q96PU5 | 23327 | NEDD4L | E3 ubiquitin-protein ligase NEDD4-like | Homo sapiens |
| PTMD12114 | Q9BTV4 | 79188 | TMEM43 | Transmembrane protein 43 | Homo sapiens |
