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Browse result for Non-alcoholic fatty liver disease

※ introduction

    Fatty liver disease (FLD), also known as hepatic steatosis and steatotic liver disease (SLD), is a condition where excess fat builds up in the liver. Often there are no or few symptoms. Occasionally there may be tiredness or pain in the upper right side of the abdomen. Complications may include cirrhosis, liver cancer, and esophageal varices. The main subtypes of fatty liver disease are metabolic dysfunction¨Cassociated steatotic liver disease (MASLD, formerly "non-alcoholic fatty liver disease" (NAFLD)) and alcohol-associated liver disease (ALD), with the category "metabolic and alcohol associated liver disease" (metALD) describing an overlap of the two. The primary risks include alcohol, type 2 diabetes, and obesity. Other risk factors include certain medications such as glucocorticoids, and hepatitis C. It is unclear why some people with NAFLD develop simple fatty liver and others develop nonalcoholic steatohepatitis (NASH), which is associated with poorer outcomes. Diagnosis is based on the medical history supported by blood tests, medical imaging, and occasionally liver biopsy. Treatment of NAFLD is generally by dietary changes and exercise to bring about weight loss. In those who are severely affected, liver transplantation may be an option. More than 90% of heavy drinkers develop fatty liver while about 25% develop the more severe alcoholic hepatitis. NAFLD affects about 30% of people in Western countries and 10% of people in Asia. NAFLD affects about 10% of children in the United States. It occurs more often in older people and males.

Reference
Wiki: Non-alcoholic fatty liver disease



PTMD IDUniProt AccessionEntrez IDGene NameProtein NameOrganism
PTMD00426P409393030
HADHA
Trifunctional enzyme subunit alpha, mitochondrial [Includes: Long-chain enoyl-CoA hydratase ; Long chain 3-hydroxyacyl-CoA dehydrogenase ]
Homo sapiens
PTMD00265P5339647
ACLY
ATP-citrate synthase -lyase)
Homo sapiens
PTMD01418O155033638
INSIG1
Insulin-induced gene 1 protein
Homo sapiens
PTMD01874Q996834217
MAP3K5
Mitogen-activated protein kinase kinase kinase 5
Homo sapiens
PTMD13453Q9NST180339
PNPLA3
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3
Homo sapiens
PTMD01420O3542622433
Xbp1
X-box-binding protein 1 [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]
Mus musculus
PTMD01656P5356612606
Cebpa
CCAAT/enhancer-binding protein alpha
Mus musculus
PTMD01841Q8R10464384
Sirt3
NAD-dependent protein deacetylase sirtuin-3
Mus musculus