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Browse result for Non-alcoholic fatty liver
※ introduction Fatty liver disease (FLD), also known as hepatic steatosis and steatotic liver disease (SLD), is a condition where excess fat builds up in the liver. Often there are no or few symptoms. Occasionally there may be tiredness or pain in the upper right side of the abdomen. Complications may include cirrhosis, liver cancer, and esophageal varices.
The main subtypes of fatty liver disease are metabolic dysfunction¨Cassociated steatotic liver disease (MASLD, formerly "non-alcoholic fatty liver disease" (NAFLD)) and alcohol-associated liver disease (ALD), with the category "metabolic and alcohol associated liver disease" (metALD) describing an overlap of the two.
The primary risks include alcohol, type 2 diabetes, and obesity. Other risk factors include certain medications such as glucocorticoids, and hepatitis C. It is unclear why some people with NAFLD develop simple fatty liver and others develop nonalcoholic steatohepatitis (NASH), which is associated with poorer outcomes. Diagnosis is based on the medical history supported by blood tests, medical imaging, and occasionally liver biopsy.
Treatment of NAFLD is generally by dietary changes and exercise to bring about weight loss. In those who are severely affected, liver transplantation may be an option. More than 90% of heavy drinkers develop fatty liver while about 25% develop the more severe alcoholic hepatitis. NAFLD affects about 30% of people in Western countries and 10% of people in Asia. NAFLD affects about 10% of children in the United States. It occurs more often in older people and males.
Reference
Wiki: Non-alcoholic fatty liver
Reference
Wiki: Non-alcoholic fatty liver
| PTMD ID | UniProt Accession | Entrez ID | Gene Name | Protein Name | Organism |
|---|---|---|---|---|---|
| PTMD00217 | P28330 | 33 | ACADL | Long-chain specific acyl-CoA dehydrogenase, mitochondrial | Homo sapiens |
| PTMD00158 | F1DAL1 | 9971 | NR1H4 | Farnesoid X nuclear receptor | Homo sapiens |
| PTMD00608 | P50416 | 1374 | CPT1A | Carnitine O-palmitoyltransferase 1, liver isoform | Homo sapiens |
| PTMD00225 | P68431 | 83508 | H3C1 | Histone H3.1 | Homo sapiens |
| PTMD00873 | P22307 | 6342 | SCP2 | Sterol carrier protein 2 | Homo sapiens |
| PTMD00417 | P36969 | 2879 | GPX4 | Phospholipid hydroperoxide glutathione peroxidase GPX4 | Homo sapiens |
| PTMD00063 | P49116 | 7182 | NR2C2 | Nuclear receptor subfamily 2 group C member 2 | Homo sapiens |
| PTMD00173 | P07900 | 3320 | HSP90AA1 | Heat shock protein HSP 90-alpha | Homo sapiens |
| PTMD00512 | P07195 | 3945 | LDHB | L-lactate dehydrogenase B chain | Homo sapiens |
| PTMD01018 | Q9Y6L6 | 10599 | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| PTMD01019 | Q9NPD5 | 28234 | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Homo sapiens |
| PTMD01020 | Q92887 | 1244 | ABCC2 | ATP-binding cassette sub-family C member 2 | Homo sapiens |
| PTMD01021 | Q14973 | 6554 | SLC10A1 | Hepatic sodium/bile acid cotransporter /bile acid cotransporter) /taurocholate transport protein) | Homo sapiens |
| PTMD01022 | O94956 | 11309 | SLCO2B1 | Solute carrier organic anion transporter family member 2B1 | Homo sapiens |
| PTMD01011 | Q13247 | 6431 | SRSF6 | Serine/arginine-rich splicing factor 6 | Homo sapiens |
| PTMD00216 | Q13085 | 31 | ACACA | Acetyl-CoA carboxylase 1 | Homo sapiens |
| PTMD01145 | Q68CJ9 | 84699 | CREB3L3 | Cyclic AMP-responsive element-binding protein 3-like protein 3 [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] | Homo sapiens |
| PTMD01375 | Q14210 | 8581 | LY6D | Lymphocyte antigen 6D | Homo sapiens |
| PTMD01739 | Q13133 | 10062 | NR1H3 | Oxysterols receptor LXR-alpha | Homo sapiens |
| PTMD00218 | Q9QYS9 | 19317 | Qki | KH domain-containing RNA-binding protein QKI | Mus musculus |
| PTMD00435 | Q80WQ6 | 21734 | Rhbdf2 | Inactive rhomboid protein 2 | Mus musculus |
| PTMD00167 | Q04207 | 19697 | Rela | Transcription factor p65 | Mus musculus |
| PTMD00930 | Q8VCR2 | 24316 | Hsd17b13 | 17-beta-hydroxysteroid dehydrogenase 13 | Mus musculus |
| PTMD00877 | Q9R1E0 | 56458 | Foxo1 | Forkhead box protein O1 | Mus musculus |
| PTMD00756 | Q923E4 | 93759 | Sirt1 | NAD-dependent protein deacetylase sirtuin-1 [Cleaved into: SirtT1 75 kDa fragment ] | Mus musculus |
| PTMD01656 | P53566 | 12606 | Cebpa | CCAAT/enhancer-binding protein alpha | Mus musculus |
