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Browse result for Non-alcoholic fatty liver

※ introduction

    Fatty liver disease (FLD), also known as hepatic steatosis and steatotic liver disease (SLD), is a condition where excess fat builds up in the liver. Often there are no or few symptoms. Occasionally there may be tiredness or pain in the upper right side of the abdomen. Complications may include cirrhosis, liver cancer, and esophageal varices. The main subtypes of fatty liver disease are metabolic dysfunction¨Cassociated steatotic liver disease (MASLD, formerly "non-alcoholic fatty liver disease" (NAFLD)) and alcohol-associated liver disease (ALD), with the category "metabolic and alcohol associated liver disease" (metALD) describing an overlap of the two. The primary risks include alcohol, type 2 diabetes, and obesity. Other risk factors include certain medications such as glucocorticoids, and hepatitis C. It is unclear why some people with NAFLD develop simple fatty liver and others develop nonalcoholic steatohepatitis (NASH), which is associated with poorer outcomes. Diagnosis is based on the medical history supported by blood tests, medical imaging, and occasionally liver biopsy. Treatment of NAFLD is generally by dietary changes and exercise to bring about weight loss. In those who are severely affected, liver transplantation may be an option. More than 90% of heavy drinkers develop fatty liver while about 25% develop the more severe alcoholic hepatitis. NAFLD affects about 30% of people in Western countries and 10% of people in Asia. NAFLD affects about 10% of children in the United States. It occurs more often in older people and males.

Reference
Wiki: Non-alcoholic fatty liver



PTMD IDUniProt AccessionEntrez IDGene NameProtein NameOrganism
PTMD00217P2833033
ACADL
Long-chain specific acyl-CoA dehydrogenase, mitochondrial
Homo sapiens
PTMD00158F1DAL19971
NR1H4
Farnesoid X nuclear receptor
Homo sapiens
PTMD00608P504161374
CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform
Homo sapiens
PTMD00225P6843183508
H3C1
Histone H3.1
Homo sapiens
PTMD00873P223076342
SCP2
Sterol carrier protein 2
Homo sapiens
PTMD00417P369692879
GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4
Homo sapiens
PTMD00063P491167182
NR2C2
Nuclear receptor subfamily 2 group C member 2
Homo sapiens
PTMD00173P079003320
HSP90AA1
Heat shock protein HSP 90-alpha
Homo sapiens
PTMD00512P071953945
LDHB
L-lactate dehydrogenase B chain
Homo sapiens
PTMD01018Q9Y6L610599
SLCO1B1
Solute carrier organic anion transporter family member 1B1
Homo sapiens
PTMD01019Q9NPD528234
SLCO1B3
Solute carrier organic anion transporter family member 1B3
Homo sapiens
PTMD01020Q928871244
ABCC2
ATP-binding cassette sub-family C member 2
Homo sapiens
PTMD01021Q149736554
SLC10A1
Hepatic sodium/bile acid cotransporter /bile acid cotransporter) /taurocholate transport protein)
Homo sapiens
PTMD01022O9495611309
SLCO2B1
Solute carrier organic anion transporter family member 2B1
Homo sapiens
PTMD01011Q132476431
SRSF6
Serine/arginine-rich splicing factor 6
Homo sapiens
PTMD00216Q1308531
ACACA
Acetyl-CoA carboxylase 1
Homo sapiens
PTMD01145Q68CJ984699
CREB3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3 [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3]
Homo sapiens
PTMD01375Q142108581
LY6D
Lymphocyte antigen 6D
Homo sapiens
PTMD01739Q1313310062
NR1H3
Oxysterols receptor LXR-alpha
Homo sapiens
PTMD00218Q9QYS919317
Qki
KH domain-containing RNA-binding protein QKI
Mus musculus
PTMD00435Q80WQ621734
Rhbdf2
Inactive rhomboid protein 2
Mus musculus
PTMD00167Q0420719697
Rela
Transcription factor p65
Mus musculus
PTMD00930Q8VCR224316
Hsd17b13
17-beta-hydroxysteroid dehydrogenase 13
Mus musculus
PTMD00877Q9R1E056458
Foxo1
Forkhead box protein O1
Mus musculus
PTMD00756Q923E493759
Sirt1
NAD-dependent protein deacetylase sirtuin-1 [Cleaved into: SirtT1 75 kDa fragment ]
Mus musculus
PTMD01656P5356612606
Cebpa
CCAAT/enhancer-binding protein alpha
Mus musculus