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Browse result for Neuropathy

※ introduction

    Peripheral neuropathy, often shortened to neuropathy, refers to damage or disease affecting the nerves. Damage to nerves may impair sensation, movement, gland function, and/or organ function depending on which nerve fibers are affected. Neuropathies affecting motor, sensory, or autonomic nerve fibers result in different symptoms. More than one type of fiber may be affected simultaneously. Peripheral neuropathy may be acute (with sudden onset, rapid progress) or chronic (symptoms begin subtly and progress slowly), and may be reversible or permanent. Common causes include systemic diseases (such as diabetes or leprosy), hyperglycemia-induced glycation, vitamin deficiency, medication (e.g., chemotherapy, or commonly prescribed antibiotics including metronidazole and the fluoroquinolone class of antibiotics (such as ciprofloxacin, levofloxacin, moxifloxacin)), traumatic injury, ischemia, radiation therapy, excessive alcohol consumption, immune system disease, celiac disease, non-celiac gluten sensitivity, or viral infection. It can also be genetic (present from birth) or idiopathic (no known cause). In conventional medical usage, the word neuropathy (neuro-, "nervous system" and -pathy, "disease of") without modifier usually means peripheral neuropathy. Neuropathy affecting just one nerve is called "mononeuropathy" and neuropathy involving nerves in roughly the same areas on both sides of the body is called "symmetrical polyneuropathy" or simply "polyneuropathy". When two or more (typically just a few, but sometimes many) separate nerves in disparate areas of the body are affected it is called "mononeuritis multiplex", "multifocal mononeuropathy", or "multiple mononeuropathy". Neuropathy may cause painful cramps, fasciculations (fine muscle twitching), muscle loss, bone degeneration, and changes in the skin, hair, and nails. Additionally, motor neuropathy may cause impaired balance and coordination or, most commonly, muscle weakness; sensory neuropathy may cause numbness to touch and vibration, reduced position sense causing poorer coordination and balance, reduced sensitivity to temperature change and pain, spontaneous tingling or burning pain, or allodynia (pain from normally nonpainful stimuli, such as light touch); and autonomic neuropathy may produce diverse symptoms, depending on the affected glands and organs, but common symptoms are poor bladder control, abnormal blood pressure or heart rate, and reduced ability to sweat normally.

Reference
Wiki: Neuropathy



PTMD IDUniProt AccessionEntrez IDGene NameProtein NameOrganism
PTMD00133O951409927
MFN2
Mitofusin-2
Homo sapiens
PTMD00055P047923315
HSPB1
Heat shock protein beta-1
Homo sapiens
PTMD00376P263581786
DNMT1
DNA -methyltransferase 1
Homo sapiens
PTMD00605P497733094
HINT1
Adenosine 5'-monophosphoramidase HINT1
Homo sapiens
PTMD01416O152709517
SPTLC2
Serine palmitoyltransferase 2
Homo sapiens
PTMD01190Q9UJY126353
HSPB8
Heat shock protein beta-8
Homo sapiens
PTMD03365O951638518
ELP1
Elongator complex protein 1
Homo sapiens
PTMD04062P111611959
EGR2
E3 SUMO-protein ligase EGR2
Homo sapiens
PTMD04562P233817453
WARS1
Tryptophan--tRNA ligase, cytoplasmic [Cleaved into: T1-TrpRS; T2-TrpRS]
Homo sapiens
PTMD04631P256863300
DNAJB2
DnaJ homolog subfamily B member 2
Homo sapiens
PTMD05008P389353508
IGHMBP2
DNA-binding protein SMUBP-2
Homo sapiens
PTMD05068P412502617
GARS1
Glycine--tRNA ligase
Homo sapiens
PTMD05259P4864322948
CCT5
T-complex protein 1 subunit epsilon
Homo sapiens
PTMD05951P783578506
CNTNAP1
Contactin-associated protein 1
Homo sapiens
PTMD06085Q007966652
SORD
Sorbitol dehydrogenase -butanediol dehydrogenase)
Homo sapiens
PTMD06177Q03001667
DST
Dystonin
Homo sapiens
PTMD10651Q8WXF751062
ATL1
Atlastin-1
Homo sapiens
PTMD10984Q96AG391137
SLC25A46
Mitochondrial outer membrane protein SLC25A46
Homo sapiens
PTMD11258Q96G9726580
BSCL2
Seipin
Homo sapiens
PTMD12801Q9H4Q459335
PRDM12
PR domain zinc finger protein 12
Homo sapiens