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Browse result for Myeloproliferative disorder

※ introduction

    Myeloproliferative neoplasms (MPNs) are a group of rare blood cancers in which excess red blood cells, white blood cells or platelets are produced in the bone marrow. Myelo refers to the bone marrow, proliferative describes the rapid growth of blood cells and neoplasm describes that growth as abnormal and uncontrolled. The overproduction of blood cells is often associated with a somatic mutation, for example in the JAK2, CALR, TET2, and MPL gene markers. In rare cases, some MPNs such as primary myelofibrosis may accelerate and turn into acute myeloid leukemia.

Reference
Wiki: Myeloproliferative disorder



PTMD IDUniProt AccessionEntrez IDGene NameProtein NameOrganism
PTMD00061O606743717
JAK2
Tyrosine-protein kinase JAK2
Homo sapiens
PTMD01730Q0835117480
Mpl
Thrombopoietin receptor
Mus musculus