※ PTMD 2.0 database Online Browse Options
Browse result for Myeloproliferative disorder
※ introduction Myeloproliferative neoplasms (MPNs) are a group of rare blood cancers in which excess red blood cells, white blood cells or platelets are produced in the bone marrow. Myelo refers to the bone marrow, proliferative describes the rapid growth of blood cells and neoplasm describes that growth as abnormal and uncontrolled.
The overproduction of blood cells is often associated with a somatic mutation, for example in the JAK2, CALR, TET2, and MPL gene markers.
In rare cases, some MPNs such as primary myelofibrosis may accelerate and turn into acute myeloid leukemia.
Reference
Wiki: Myeloproliferative disorder
Reference
Wiki: Myeloproliferative disorder
| PTMD ID | UniProt Accession | Entrez ID | Gene Name | Protein Name | Organism |
|---|---|---|---|---|---|
| PTMD00061 | O60674 | 3717 | JAK2 | Tyrosine-protein kinase JAK2 | Homo sapiens |
| PTMD01730 | Q08351 | 17480 | Mpl | Thrombopoietin receptor | Mus musculus |
