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Browse result for Maturity-onset diabetes of the young
※ introduction Maturity-onset diabetes of the young (MODY) refers to any of several hereditary forms of diabetes mellitus caused by mutations in an autosomal dominant gene disrupting insulin production. Along with neonatal diabetes, MODY is a form of the conditions known as monogenic diabetes. While the more common types of diabetes (especially type 1 and type 2) involve more complex combinations of causes involving multiple genes and environmental factors, each forms of MODY are caused by changes to a single gene (monogenic). GCK-MODY (MODY 2) and HNF1A-MODY (MODY 3) are the most common forms.
Robert Tattersall and Stefan Fajans initially identified the phenomenon known as maturity onset diabetes of the young in a classic study published in the journal Diabetes in 1975.
Reference
Wiki: Maturity-onset diabetes of the young
Reference
Wiki: Maturity-onset diabetes of the young
| PTMD ID | UniProt Accession | Entrez ID | Gene Name | Protein Name | Organism |
|---|---|---|---|---|---|
| PTMD04450 | P20823 | 6927 | HNF1A | Hepatocyte nuclear factor 1-alpha | Homo sapiens |
| PTMD04939 | P35557 | 2645 | GCK | Hexokinase-4 | Homo sapiens |
| PTMD05064 | P41235 | 3172 | HNF4A | Hepatocyte nuclear factor 4-alpha | Homo sapiens |
| PTMD05422 | P51451 | 640 | BLK | Tyrosine-protein kinase Blk | Homo sapiens |
| PTMD06784 | Q14654 | 3767 | KCNJ11 | ATP-sensitive inward rectifier potassium channel 11 channel Kir6.2) | Homo sapiens |
| PTMD14301 | Q9UKG1 | 26060 | APPL1 | DCC-interacting protein 13-alpha | Homo sapiens |
