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Browse result for Lymphoma

※ introduction

    Lymphoma is a group of blood and lymph tumors that develop from lymphocytes (a type of white blood cell). The name typically refers to just the cancerous versions rather than all such tumours. Signs and symptoms may include enlarged lymph nodes, fever, drenching sweats, unintended weight loss, itching, and constantly feeling tired. The enlarged lymph nodes are usually painless. The sweats are most common at night. Many subtypes of lymphomas are known. The two main categories of lymphomas are the non-Hodgkin lymphoma (NHL) (90% of cases) and Hodgkin lymphoma (HL) (10%). Lymphomas, leukemias and myelomas are a part of the broader group of tumors of the hematopoietic and lymphoid tissues. Risk factors for Hodgkin lymphoma include infection with Epstein¨CBarr virus and a history of the disease in the family. Risk factors for common types of non-Hodgkin lymphomas include autoimmune diseases, HIV/AIDS, infection with human T-lymphotropic virus, immunosuppressant medications, and some pesticides. In 2014, the International Agency for Research on Cancer updated its classification of trichloroethylene to Group 1, indicating that sufficient evidence exists that it causes cancer of the kidney in humans as well as some evidence of cancer of the liver and non-Hodgkin's lymphoma. Eating large amounts of red meat and tobacco smoking may also increase the risk. Diagnosis, if enlarged lymph nodes are present, is usually by lymph node biopsy. Blood, urine, and bone marrow testing may also be useful in the diagnosis. Medical imaging may then be done to determine if and where the cancer has spread. Lymphoma most often spreads to the lungs, liver, and brain. Treatment may involve one or more of the following: chemotherapy, radiation therapy, proton therapy, targeted therapy, and surgery. In some non-Hodgkin lymphomas, an increased amount of protein produced by the lymphoma cells causes the blood to become so thick that plasmapheresis is performed to remove the protein. Watchful waiting may be appropriate for certain types. The outcome depends on the subtype with some being curable and treatment prolonging survival in most. The five-year survival rate in the United States for all Hodgkin lymphoma subtypes is 85%, while that for non-Hodgkin lymphomas is 69%. Worldwide, lymphomas developed in 566,000 people in 2012 and caused 305,000 deaths. They make up 3¨C4% of all cancers, making them as a group the seventh-most common form. In children, they are the third-most common cancer. They occur more often in the developed world than the developing world.

Reference
Wiki: Lymphoma



PTMD IDUniProt AccessionEntrez IDGene NameProtein NameOrganism
PTMD00592P41182604
BCL6
B-cell lymphoma 6 protein
Homo sapiens
PTMD00333Q157171994
ELAVL1
ELAV-like protein 1
Homo sapiens
PTMD00863P024521277
COL1A1
Collagen alpha-1 chain
Homo sapiens
PTMD00144Q129337186
TRAF2
TNF receptor-associated factor 2
Homo sapiens
PTMD00955O959998915
BCL10
B-cell lymphoma/leukemia 10
Homo sapiens
PTMD00945Q165391432
MAPK14
Mitogen-activated protein kinase 14
Homo sapiens
PTMD00065P284825594
MAPK1
Mitogen-activated protein kinase 1
Homo sapiens
PTMD00058P273615595
MAPK3
Mitogen-activated protein kinase 3
Homo sapiens
PTMD00031P465271027
CDKN1B
Cyclin-dependent kinase inhibitor 1B
Homo sapiens
PTMD00179P465314851
NOTCH1
Neurogenic locus notch homolog protein 1 [Cleaved into: Notch 1 extracellular truncation ; Notch 1 intracellular domain ]
Homo sapiens
PTMD00224P6280512150
H4C1
Histone H4
Homo sapiens
PTMD00213P422246772
STAT1
Signal transducer and activator of transcription 1-alpha/beta
Homo sapiens
PTMD00957O155248651
SOCS1
Suppressor of cytokine signaling 1
Homo sapiens
PTMD00019P041502908
NR3C1
Glucocorticoid receptor
Homo sapiens
PTMD00006P046377157
TP53
Cellular tumor antigen p53
Homo sapiens
PTMD00202P085814233
MET
Hepatocyte growth factor receptor
Homo sapiens
PTMD00040P407636774
STAT3
Signal transducer and activator of transcription 3
Homo sapiens
PTMD00906P422266778
STAT6
Signal transducer and activator of transcription 6
Homo sapiens
PTMD00941P422296776
STAT5A
Signal transducer and activator of transcription 5A
Homo sapiens
PTMD00041P498412932
GSK3B
Glycogen synthase kinase-3 beta
Homo sapiens
PTMD00660Q061245781
PTPN11
Tyrosine-protein phosphatase non-receptor type 11
Homo sapiens
PTMD00231Q136168454
CUL1
Cullin-1
Homo sapiens
PTMD01360P155294179
CD46
Membrane cofactor protein
Homo sapiens
PTMD01101P516926777
STAT5B
Signal transducer and activator of transcription 5B
Homo sapiens
PTMD01673P565373692
EIF6
Eukaryotic translation initiation factor 6 GCN homolog) )
Homo sapiens
PTMD00928Q80YR622518
Rbbp8
DNA endonuclease RBBP8
Mus musculus
PTMD00499P0234022059
Tp53
Cellular tumor antigen p53
Mus musculus
PTMD01347P2268212402
Cbl
E3 ubiquitin-protein ligase CBL
Mus musculus