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Browse result for Left ventricular noncompaction
※ introduction Noncompaction cardiomyopathy (NCC) is a rare congenital disease of heart muscle that affects both children and adults. It results from abnormal prenatal development of heart muscle.
During development, the majority of the heart muscle is a sponge-like meshwork of interwoven myocardial fibers. As normal development progresses, these trabeculated structures undergo significant compaction that transforms them from spongy to solid. This process is particularly apparent in the ventricles, and particularly so in the left ventricle. Noncompaction cardiomyopathy results when there is failure of this process of compaction. Because the consequence of non-compaction is particularly evident in the left ventricle, the condition is also called left ventricular noncompaction. Other hypotheses and models have been proposed, none of which is as widely accepted as the noncompaction model.
Symptoms range greatly in severity. Most are a result of a poor pumping performance by the heart. The disease can be associated with other problems with the heart and the body.
Reference
Wiki: Left ventricular noncompaction
Reference
Wiki: Left ventricular noncompaction
| PTMD ID | UniProt Accession | Entrez ID | Gene Name | Protein Name | Organism |
|---|---|---|---|---|---|
| PTMD01064 | P09493 | 7168 | TPM1 | Tropomyosin alpha-1 chain | Homo sapiens |
| PTMD01525 | P15924 | 1832 | DSP | Desmoplakin | Homo sapiens |
| PTMD01694 | P68032 | 70 | ACTC1 | Actin, alpha cardiac muscle 1 [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Homo sapiens |
| PTMD01751 | Q14524 | 6331 | SCN5A | Sodium channel protein type 5 subunit alpha | Homo sapiens |
| PTMD01131 | Q14896 | 4607 | MYBPC3 | Myosin-binding protein C, cardiac-type | Homo sapiens |
| PTMD01878 | Q9BR39 | 57158 | JPH2 | Junctophilin-2 [Cleaved into: Junctophilin-2 N-terminal fragment ] | Homo sapiens |
| PTMD04130 | P12883 | 4625 | MYH7 | Myosin-7 | Homo sapiens |
| PTMD06704 | Q14192 | 2274 | FHL2 | Four and a half LIM domains protein 2 | Homo sapiens |
| PTMD13046 | Q9HAZ2 | 63976 | PRDM16 | Histone-lysine N-methyltransferase PRDM16 | Homo sapiens |
| PTMD14855 | Q9Y4J8 | 1837 | DTNA | Dystrobrevin alpha | Homo sapiens |
