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Browse result for Hypertension

※ introduction

    Hypertension, also known as high blood pressure, is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. High blood pressure usually does not cause symptoms itself. It is, however, a major risk factor for stroke, coronary artery disease, heart failure, atrial fibrillation, peripheral arterial disease, vision loss, chronic kidney disease, and dementia. Hypertension is a major cause of premature death worldwide. High blood pressure is classified as primary (essential) hypertension or secondary hypertension. About 90¨C95% of cases are primary, defined as high blood pressure due to nonspecific lifestyle and genetic factors. Lifestyle factors that increase the risk include excess salt in the diet, excess body weight, smoking, physical inactivity and alcohol use. The remaining 5¨C10% of cases are categorized as secondary high blood pressure, defined as high blood pressure due to a clearly identifiable cause, such as chronic kidney disease, narrowing of the kidney arteries, an endocrine disorder, or the use of birth control pills. Blood pressure is classified by two measurements, the systolic (first number) and diastolic (second number) pressures. For most adults, normal blood pressure at rest is within the range of 100¨C130 millimeters mercury (mmHg) systolic and 60¨C80 mmHg diastolic. For most adults, high blood pressure is present if the resting blood pressure is persistently at or above 130/80 or 140/90 mmHg. Different numbers apply to children. Ambulatory blood pressure monitoring over a 24-hour period appears more accurate than office-based blood pressure measurement. Hypertension is around twice as common in diabetics. Lifestyle changes and medications can lower blood pressure and decrease the risk of health complications. Lifestyle changes include weight loss, physical exercise, decreased salt intake, reducing alcohol intake, and a healthy diet. If lifestyle changes are not sufficient, then blood pressure medications are used. Up to three medications taken concurrently can control blood pressure in 90% of people. The treatment of moderately high arterial blood pressure (defined as >160/100 mmHg) with medications is associated with an improved life expectancy. The effect of treatment of blood pressure between 130/80 mmHg and 160/100 mmHg is less clear, with some reviews finding benefit and others finding unclear benefit. High blood pressure affects between 16 and 37% of the population globally. In 2010 hypertension was believed to have been a factor in 17.8% of all deaths (9.4 million globally).

Reference
Wiki: Hypertension



PTMD IDUniProt AccessionEntrez IDGene NameProtein NameOrganism
PTMD00338P106364137
MAPT
Microtubule-associated protein tau
Homo sapiens
PTMD01080P294744846
NOS3
Nitric oxide synthase 3
Homo sapiens
PTMD01750Q144325139
PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Homo sapiens
PTMD01865Q96RD724145
PANX1
Pannexin-1 [Cleaved into: Caspase-activated pannexin-1 ]
Homo sapiens
PTMD01471P0519729565
Eef2
Elongation factor 2
Rattus norvegicus
PTMD01490P0805024392
Gja1
Gap junction alpha-1 protein
Rattus norvegicus
PTMD01492P0841324245
Camk2b
Calcium/calmodulin-dependent protein kinase type II subunit beta
Rattus norvegicus
PTMD01701P7053125435
Eef2k
Eukaryotic elongation factor 2 kinase
Rattus norvegicus
PTMD01713Q0096024410
Grin2b
Glutamate receptor ionotropic, NMDA 2B
Rattus norvegicus