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Browse result for Glanzmann thrombasthenia

※ introduction

    Glanzmann's thrombasthenia is an abnormality of the platelets. It is an extremely rare coagulopathy (bleeding disorder due to a blood abnormality), in which the platelets contain defective or low levels of glycoprotein IIb/IIIa (GpIIb/IIIa), which is a receptor for fibrinogen. As a result, no fibrinogen bridging of platelets to other platelets can occur, and the bleeding time is significantly prolonged.

Reference
Wiki: Glanzmann thrombasthenia



PTMD IDUniProt AccessionEntrez IDGene NameProtein NameOrganism
PTMD00889P085143674
ITGA2B
Integrin alpha-IIb [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2]
Homo sapiens
PTMD01222P051063690
ITGB3
Integrin beta-3
Homo sapiens