※ PTMD 2.0 database Online Browse Options

Browse result for Gastric intestinal metaplasia and cancer

※ introduction

    Intestinal metaplasia is the transformation (metaplasia) of epithelium (usually of the stomach or the esophagus) into a type of epithelium resembling that found in the intestine. In the esophagus, this is called Barrett's esophagus. Chronic inflammation caused by H. pylori infection in the stomach and GERD in the esophagus are seen as the primary instigators of metaplasia and subsequent adenocarcinoma formation. Initially, the transformed epithelium resembles the small intestine lining; in the later stages it resembles the lining of the colon. It is characterized by the appearance of goblet cells and expression of intestinal cell markers such as the transcription factor, CDX2.

Reference
Wiki: Gastric intestinal metaplasia and cancer



PTMD IDUniProt AccessionEntrez IDGene NameProtein NameOrganism
PTMD01305P051096279
S100A8
Protein S100-A8
Homo sapiens