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Browse result for Diabetes mellitus
※ introduction Diabetes mellitus, often known simply as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body becoming unresponsive to the hormone's effects. Classic symptoms include thirst, polyuria, weight loss, and blurred vision. If left untreated, the disease can lead to various health complications, including disorders of the cardiovascular system, eye, kidney, and nerves. Untreated or poorly treated diabetes accounts for approximately 1.5 million deaths every year.
The major types of diabetes are type 1 and type 2. The most common treatment for type 1 is insulin replacement therapy (insulin injections), while anti-diabetic medications (such as metformin and semaglutide) and lifestyle modifications can be used to manage type 2. Gestational diabetes, a form that arises during pregnancy in some women, normally resolves shortly after delivery.
As of 2021, an estimated 537 million people had diabetes worldwide accounting for 10.5% of the adult population, with type 2 making up about 90% of all cases. It is estimated that by 2045, approximately 783 million adults, or 1 in 8, will be living with diabetes, representing a 46% increase from the current figures. The prevalence of the disease continues to increase, most dramatically in low- and middle-income nations. Rates are similar in women and men, with diabetes being the seventh leading cause of death globally. The global expenditure on diabetes-related healthcare is an estimated US$760 billion a year.
Reference
Wiki: Diabetes mellitus
Reference
Wiki: Diabetes mellitus
| PTMD ID | UniProt Accession | Entrez ID | Gene Name | Protein Name | Organism |
|---|---|---|---|---|---|
| PTMD00241 | P31751 | 208 | AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens |
| PTMD00946 | P35568 | 3667 | IRS1 | Insulin receptor substrate 1 | Homo sapiens |
| PTMD00491 | O95644 | 4772 | NFATC1 | Nuclear factor of activated T-cells, cytoplasmic 1 | Homo sapiens |
| PTMD00049 | P31749 | 207 | AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens |
| PTMD00338 | P10636 | 4137 | MAPT | Microtubule-associated protein tau | Homo sapiens |
| PTMD00168 | P05412 | 3725 | JUN | Transcription factor Jun | Homo sapiens |
| PTMD00313 | P08047 | 6667 | SP1 | Transcription factor Sp1 | Homo sapiens |
| PTMD00943 | P23443 | 6198 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Homo sapiens |
| PTMD00022 | P46937 | 10413 | YAP1 | Transcriptional coactivator YAP1 | Homo sapiens |
| PTMD00041 | P49841 | 2932 | GSK3B | Glycogen synthase kinase-3 beta | Homo sapiens |
| PTMD00225 | P68431 | 83508 | H3C1 | Histone H3.1 | Homo sapiens |
| PTMD01475 | P06213 | 3643 | INSR | Insulin receptor [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Homo sapiens |
| PTMD01080 | P29474 | 4846 | NOS3 | Nitric oxide synthase 3 | Homo sapiens |
| PTMD01430 | O60343 | 9882 | TBC1D4 | TBC1 domain family member 4 | Homo sapiens |
| PTMD01431 | O60500 | 4868 | NPHS1 | Nephrin | Homo sapiens |
| PTMD01054 | P02489 | 10272 | CRYAA | Alpha-crystallin A chain [Cleaved into: Alpha-crystallin A; Alpha-crystallin A; Alpha-crystallin A] | Homo sapiens |
| PTMD01481 | P06576 | 506 | ATP5F1B | ATP synthase subunit beta, mitochondrial | Homo sapiens |
| PTMD01517 | P13807 | 2997 | GYS1 | Glycogen [starch] synthase, muscle | Homo sapiens |
| PTMD01722 | Q04760 | 2739 | GLO1 | Lactoylglutathione lyase | Homo sapiens |
| PTMD01815 | Q6ZMU5 | 49382 | TRIM72 | Tripartite motif-containing protein 72 | Homo sapiens |
| PTMD01852 | Q92879 | 10658 | CELF1 | CUGBP Elav-like family member 1 | Homo sapiens |
| PTMD05129 | P43304 | 2820 | GPD2 | Glycerol-3-phosphate dehydrogenase, mitochondrial | Homo sapiens |
| PTMD05204 | P47871 | 2642 | GCGR | Glucagon receptor | Homo sapiens |
| PTMD05531 | P52945 | 3651 | PDX1 | Pancreas/duodenum homeobox protein 1 | Homo sapiens |
| PTMD00920 | Q0PCR6 | 12288 | Cacna1c | Voltage-dependent L-type calcium channel subunit alpha | Mus musculus |
| PTMD00877 | Q9R1E0 | 56458 | Foxo1 | Forkhead box protein O1 | Mus musculus |
| PTMD00526 | P10637 | 17762 | Mapt | Microtubule-associated protein tau | Mus musculus |
| PTMD00580 | P31750 | 11651 | Akt1 | RAC-alpha serine/threonine-protein kinase | Mus musculus |
| PTMD00167 | Q04207 | 19697 | Rela | Transcription factor p65 | Mus musculus |
| PTMD00715 | Q60795 | 18024 | Nfe2l2 | Nuclear factor erythroid 2-related factor 2 | Mus musculus |
| PTMD00206 | Q7TQN4 | 30916 | Rela | Nuclear factor kappaB subunit p65 ) | Rattus norvegicus |
| PTMD01607 | P35569 | 16367 | Irs1 | Insulin receptor substrate 1 | Mus musculus |
| PTMD01340 | P35570 | 25467 | Irs1 | Insulin receptor substrate 1 | Rattus norvegicus |
| PTMD01152 | Q8BYJ6 | 21078 | Tbc1d4 | TBC1 domain family member 4 | Mus musculus |
| PTMD01396 | B0LPN4 | 68956 | Ryr2 | Ryanodine receptor 2 | Rattus norvegicus |
| PTMD01397 | B5DEX4 | 36151 | Vasp | Vasp protein | Rattus norvegicus |
| PTMD01400 | E9Q401 | 20191 | Ryr2 | Ryanodine receptor 2 | Mus musculus |
| PTMD01490 | P08050 | 24392 | Gja1 | Gap junction alpha-1 protein | Rattus norvegicus |
| PTMD01492 | P08413 | 24245 | Camk2b | Calcium/calmodulin-dependent protein kinase type II subunit beta | Rattus norvegicus |
| PTMD01498 | P09951 | 24949 | Syn1 | Synapsin-1 | Rattus norvegicus |
| PTMD01538 | P18266 | 84027 | Gsk3b | Glycogen synthase kinase-3 beta | Rattus norvegicus |
| PTMD01542 | P19332 | Mapt | Microtubule-associated protein tau | Rattus norvegicus | |
| PTMD01545 | P19490 | 50592 | Gria1 | Glutamate receptor 1 | Rattus norvegicus |
| PTMD01556 | P23928 | 25420 | Cryab | Alpha-crystallin B chain -crystallin) | Rattus norvegicus |
| PTMD01559 | P24622 | 12954 | Cryaa | Alpha-crystallin A chain | Mus musculus |
| PTMD01563 | P25976 | Ubtf | Nucleolar transcription factor 1 | Mus musculus | |
| PTMD01564 | P25977 | 25574 | Ubtf | Nucleolar transcription factor 1 | Rattus norvegicus |
| PTMD01569 | P27546 | 17758 | Map4 | Microtubule-associated protein 4 | Mus musculus |
| PTMD01597 | P33535 | 25601 | Oprm1 | Mu-type opioid receptor | Rattus norvegicus |
| PTMD01599 | P34080 | 25386 | Aqp2 | Aquaporin-2 | Rattus norvegicus |
| PTMD01604 | P35486 | 18597 | Pdha1 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | Mus musculus |
| PTMD01631 | P46938 | 22601 | Yap1 | Transcriptional coactivator YAP1 | Mus musculus |
| PTMD01357 | P61016 | 64672 | Pln | Cardiac phospholamban | Rattus norvegicus |
| PTMD01698 | P70313 | 18127 | Nos3 | Nitric oxide synthase 3 | Mus musculus |
| PTMD01777 | Q2NL51 | 60649 | Gsk3a | Glycogen synthase kinase-3 alpha | Mus musculus |
| PTMD01781 | Q3LRZ1 | 31061 | Crtc2 | CREB-regulated transcription coactivator 2 | Rattus norvegicus |
| PTMD01786 | Q5EG47 | 10578 | Prkaa1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Mus musculus |
| PTMD01788 | Q5SWU9 | 10747 | Acaca | Acetyl-CoA carboxylase 1 | Mus musculus |
| PTMD01796 | Q61553 | 14086 | Fscn1 | Fascin | Mus musculus |
| PTMD01799 | Q62600 | 24600 | Nos3 | Nitric oxide synthase 3 | Rattus norvegicus |
| PTMD01805 | Q6LED0 | 29115 | Histone H3.1 | Rattus norvegicus | |
| PTMD01830 | Q8CHW4 | 22404 | Eif2b5 | Translation initiation factor eIF2B subunit epsilon | Mus musculus |
| PTMD01836 | Q8K1M6 | 74006 | Dnm1l | Dynamin-1-like protein | Mus musculus |
| PTMD01887 | Q9D023 | 70456 | Mpc2 | Mitochondrial pyruvate carrier 2 | Mus musculus |
| PTMD01888 | Q9D1F4 | 67605 | Akt1s1 | Proline-rich AKT1 substrate 1 | Mus musculus |
| PTMD01889 | Q9DBR7 | 17931 | Ppp1r12a | Protein phosphatase 1 regulatory subunit 12A | Mus musculus |
| PTMD01921 | Q9R1U5 | 59329 | Sik1 | Serine/threonine-protein kinase SIK1 | Rattus norvegicus |
| PTMD01390 | Q9WV60 | 56637 | Gsk3b | Glycogen synthase kinase-3 beta | Mus musculus |
| PTMD01938 | Q9WVS8 | 23939 | Mapk7 | Mitogen-activated protein kinase 7 | Mus musculus |
| PTMD01952 | Q9Z0J4 | 18125 | Nos1 | Nitric oxide synthase 1 | Mus musculus |
| PTMD01961 | Q9Z301 | 63840 | Per2 | Period circadian protein homolog 2 | Rattus norvegicus |
