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Browse result for Cryptorchidism

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    Cryptorchidism, also known as undescended testis, is the failure of one or both testes to descend into the scrotum. The word is from Greek ¦Ê¦Ñ¦Ô¦Ð¦Ó?? (kryptos) 'hidden' and ?¦Ñ¦Ö¦É? (orchis) 'testicle'. It is the most common birth defect of the male genital tract. About 3% of full-term and 30% of premature infant boys are born with at least one undescended testis. However, about 80% of cryptorchid testes descend by the first year of life (the majority within three months), making the true incidence of cryptorchidism around 1% overall. Cryptorchidism may develop after infancy, sometimes as late as young adulthood, but that is exceptional. Cryptorchidism is distinct from monorchism, the condition of having only one testicle. Though the condition may occur on one or both sides, it more commonly affects the right testis. A testis absent from the normal scrotal position may be: Anywhere along the "path of descent" from high in the posterior (retroperitoneal) abdomen, just below the kidney, to the inguinal ring In the inguinal canal Ectopic, having "wandered" from the path of descent, usually outside the inguinal canal and sometimes even under the skin of the thigh, the perineum, the opposite scrotum, or the femoral canal Undeveloped (hypoplastic) or severely abnormal (dysgenetic) Missing (also see anorchia). About two-thirds of cases without other abnormalities are unilateral; most of the other third involve both testes. In 90% of cases, an undescended testis can be felt in the inguinal canal. In a small minority of cases, missing testes may be found in the abdomen or appear to be nonexistent (truly "hidden"). Undescended testes are associated with reduced fertility, increased risk of testicular germ-cell tumors, and psychological problems when fully-grown. Undescended testes are also more susceptible to testicular torsion (and subsequent infarction) and inguinal hernias. Without intervention, an undescended testicle will usually descend during the first year of life, but to reduce these risks, undescended testes can be brought into the scrotum in infancy by a surgical procedure called an orchiopexy. Although cryptorchidism nearly always refers to congenital absence or maldescent, a testis observed in the scrotum in early infancy can occasionally "reascend" (move back up) into the inguinal canal. A testis that can readily move or be moved between the scrotum and canal is referred to as retractile. Cryptorchidism, hypospadias, testicular cancer, and poor semen quality make up the syndrome known as testicular dysgenesis syndrome.

Reference
Wiki: Cryptorchidism



PTMD IDUniProt AccessionEntrez IDGene NameProtein NameOrganism
PTMD00990P105151737
DLAT
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Homo sapiens
PTMD00587P365075605
MAP2K2
Dual specificity mitogen-activated protein kinase kinase 2
Homo sapiens
PTMD00631P631047534
YWHAZ
14-3-3 protein zeta/delta
Homo sapiens
PTMD08783Q7Z3B328405
KANSL1
KAT8 regulatory NSL complex subunit 1
Homo sapiens
PTMD10660Q8WXI957459
GATAD2B
Transcriptional repressor p66-beta
Homo sapiens