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Browse result for Craniosynostosis

※ introduction

    Craniosynostosis is a condition in which one or more of the fibrous sutures in a young infant's skull prematurely fuses by turning into bone (ossification), thereby changing the growth pattern of the skull. Because the skull cannot expand perpendicular to the fused suture, it compensates by growing more in the direction parallel to the closed sutures. Sometimes the resulting growth pattern provides the necessary space for the growing brain, but results in an abnormal head shape and abnormal facial features. In cases in which the compensation does not effectively provide enough space for the growing brain, craniosynostosis results in increased intracranial pressure leading possibly to visual impairment, sleeping impairment, eating difficulties, or an impairment of mental development combined with a significant reduction in IQ. Craniosynostosis occurs in one in 2000 births. Craniosynostosis is part of a syndrome in 15% to 40% of affected patients, but it usually occurs as an isolated condition. The term is from cranio, cranium; + syn, together; + ost, relating to bone; + osis, denoting a condition. Craniosynostosis is the opposite of metopism.

Reference
Wiki: Craniosynostosis



PTMD IDUniProt AccessionEntrez IDGene NameProtein NameOrganism
PTMD00037Q156727291
TWIST1
Twist-related protein 1
Homo sapiens
PTMD02716O435414091
SMAD6
Mothers against decapentaplegic homolog 6
Homo sapiens
PTMD04527P226072261
FGFR3
Fibroblast growth factor receptor 3
Homo sapiens
PTMD05388P505482077
ERF
ETS domain-containing transcription factor ERF
Homo sapiens
PTMD11791Q990816938
TCF12
Transcription factor 12
Homo sapiens