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Browse result for Corticotroph tumor

※ introduction

    Corticotropes (or corticotrophs) are basophilic cells in the anterior pituitary that produce pro-opiomelanocortin (POMC) which undergoes cleavage to adrenocorticotropin (ACTH), ¦Â-lipotropin (¦Â-LPH), and melanocyte-stimulating hormone (MSH). These cells are stimulated by corticotropin releasing hormone (CRH) and make up 15¨C20% of the cells in the anterior pituitary. The release of ACTH from the corticotropic cells is controlled by CRH, which is formed in the cell bodies of parvocellular neurosecretory cells within the paraventricular nucleus of the hypothalamus and passes to the corticotropes in the anterior pituitary via the hypophyseal portal system. Adrenocorticotropin hormone stimulates the adrenal cortex to release glucocorticoids and plays an important role in the stress response.

Reference
Wiki: Corticotroph tumor



PTMD IDUniProt AccessionEntrez IDGene NameProtein NameOrganism
PTMD00031P465271027
CDKN1B
Cyclin-dependent kinase inhibitor 1B
Homo sapiens