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Browse result for Cervical cancer/carcinoma

※ introduction

    Cervical cancer is a cancer arising from the cervix or in the any layer of the wall of the cervix. It is due to the abnormal growth of cells that have the ability to invade or spread to other parts of the body. Early on, typically no symptoms are seen. Later symptoms may include abnormal vaginal bleeding, pelvic pain or pain during sexual intercourse. While bleeding after sex may not be serious, it may also indicate the presence of cervical cancer. Human papillomavirus infection (HPV) causes more than 90% of cases; most who have had HPV infections, however, do not develop cervical cancer. HPV 16 and 18 strains are responsible for nearly 50% of high grade cervical pre-cancers. Other risk factors include smoking, a weak immune system, birth control pills, starting sex at a young age, and having many sexual partners, but these are less important. Genetic factors also contribute to cervical cancer risk. Cervical cancer typically develops from precancerous changes called cervical intraepithelial neoplasia over 10 to 20 years. About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. Diagnosis is typically by cervical screening followed by a biopsy. Medical imaging is then done to determine whether or not the cancer has spread. HPV vaccines protect against two to seven high-risk strains of this family of viruses and may prevent up to 90% of cervical cancers. As a risk of cancer still exists, guidelines recommend continuing regular Pap tests. Other methods of prevention include having few or no sexual partners and the use of condoms. Cervical cancer screening using the Pap test or acetic acid can identify precancerous changes, which when treated, can prevent the development of cancer. Treatment may consist of some combination of surgery, chemotherapy, and radiation therapy. Five-year survival rates in the United States are 68%. Outcomes, however, depend very much on how early the cancer is detected. Worldwide, cervical cancer is both the fourth-most common type of cancer and the fourth-most common cause of death from cancer in women. In 2012, an estimated 528,000 cases of cervical cancer occurred, with 266,000 deaths. This is about 8% of the total cases and total deaths from cancer. About 70% of cervical cancers and 90% of deaths occur in developing countries. In low-income countries, it is one of the most common causes of cancer death with an incidence rate of 47.3 per 100,000 women. In developed countries, the widespread use of cervical screening programs has dramatically reduced rates of cervical cancer. Expected scenarios for the reduction of mortality due to cervical cancer worldwide (and specially in low-income countries) have been reviewed, given assumptions with respect to the achievement of recommended prevention targets using triple-intervention strategies defined by WHO. In medical research, the most famous immortalized cell line, known as HeLa, was developed from cervical cancer cells of a woman named Henrietta Lacks.

Reference
Wiki: Cervical cancer/carcinoma



PTMD IDUniProt AccessionEntrez IDGene NameProtein NameOrganism
PTMD00619P533505347
PLK1
Serine/threonine-protein kinase PLK1
Homo sapiens
PTMD00027P011064609
MYC
Myc proto-oncogene protein
Homo sapiens
PTMD00221P09874142
PARP1
Poly [ADP-ribose] polymerase 1 ADP-ribosyltransferase 1) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus ; Poly [ADP-ribose] polymerase 1, processed N-terminus ]
Homo sapiens
PTMD00522P0DMV833033
HSPA1A
Heat shock 70 kDa protein 1A
Homo sapiens
PTMD00022P4693710413
YAP1
Transcriptional coactivator YAP1
Homo sapiens
PTMD00607P502814323
MMP14
Matrix metalloproteinase-14
Homo sapiens
PTMD00049P31749207
AKT1
RAC-alpha serine/threonine-protein kinase
Homo sapiens
PTMD00021P129316714
SRC
Proto-oncogene tyrosine-protein kinase Src
Homo sapiens
PTMD00210Q053975747
PTK2
Focal adhesion kinase 1
Homo sapiens
PTMD00508P051981965
EIF2S1
Eukaryotic translation initiation factor 2 subunit 1
Homo sapiens
PTMD00571P293171969
EPHA2
Ephrin type-A receptor 2
Homo sapiens
PTMD00225P6843183508
H3C1
Histone H3.1
Homo sapiens
PTMD00768Q96B3684335
AKT1S1
Proline-rich AKT1 substrate 1
Homo sapiens
PTMD01165Q96GD49212
AURKB
Aurora kinase B
Homo sapiens
PTMD01546P206185689
PSMB1
Proteasome subunit beta type-1
Homo sapiens