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Browse result for Aortic aneurysm

※ introduction

    An aortic aneurysm is an enlargement (dilatation) of the aorta to greater than 1.5 times normal size. They usually cause no symptoms except when ruptured. Occasionally, there may be abdominal, back, or leg pain. The prevalence of abdominal aortic aneurysm ("AAA") has been reported to range from 2 to 12% and is found in about 8% of men more than 65 years of age. The mortality rate attributable to AAA is about 15,000 per year in the United States and 6,000 to 8,000 per year in the United Kingdom and Ireland. Between 2001 and 2006, there were approximately 230,000 AAA surgical repairs performed on Medicare patients in the United States. The etiology remains an area of active research. Known causes include trauma, infection, and inflammatory disorders. Risk factors include cigarette smoking, advanced age, dyslipidemia, hypertension, and coronary artery disease. The pathophysiology of the disease is related to an initial arterial insult causing a cascade of inflammation and extracellular matrix protein breakdown by proteinases leading to arterial wall weakening. They are most commonly located in the abdominal aorta, but can also be located in the thoracic aorta. Aortic aneurysms result from a weakness in the wall of the aorta and increase the risk of aortic rupture. When rupture occurs, massive internal bleeding results and, unless treated immediately, shock and death can occur. Screening with ultrasound is indicated in those at high risk. Prevention is by decreasing risk factors, such as smoking, and treatment is either by open or endovascular surgery. Aortic aneurysms resulted in about 152,000 deaths worldwide in 2013, up from 100,000 in 1990.

Reference
Wiki: Aortic aneurysm



PTMD IDUniProt AccessionEntrez IDGene NameProtein NameOrganism
PTMD00252P840224088
SMAD3
Mothers against decapentaplegic homolog 3
Homo sapiens
PTMD00700Q157464638
MYLK
Myosin light chain kinase, smooth muscle [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]
Homo sapiens
PTMD04957P357494629
MYH11
Myosin-11
Homo sapiens
PTMD05876P6273659
ACTA2
Actin, aortic smooth muscle [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Homo sapiens