Post translational modification (PTM) is an important biochemical process, which occurs after the mRNA is translated into the protein sequence in ribosomes. PTM is involved in nearly all aspect of biological processes by regulation of protein function. Abnormal PTM status has been reported to be associated with a variety of diseases, including cancers and neurologic diseases (Wesseling, Hendrik et al., 2020; Geffen, Yifat et al., 2023; Kacen, Assaf et al., 2023; Chen, Ling et al., 2020). PTM process the protein by adding different biochemical group (such as phosphorylation (Malik, Nazma et al., 2023), acetylation (Mews, P et al., 2019), by adding different small protein molecule (such as ubiquitination (González, Alexis et al., 2023), sumoylation (Zhao, Xu et al., 2022), and by splicing protein sequence at specific sites (such as caspase cascade (Zamaraev, Alexey V et al., 2017). more details >>>

    Here we provide PTMD 2.0 (PTMs that are associated with human Diseases), an integrative resource that contains 342,624 PTMs-disease associations (PDAs) in 15,105 proteins for 93 PTM types and 2,083 diseases. In this work, we manually collected 6,739 high-quality, experimentally identified PDAs from over 800,000 pieces of literature, with detailed descriptions on PTM-disease relations taken from the primary references. Additionally, we integrated and processed potential 335,885 PDAs from three databases of ActiveDriverDB, BioMuta and PhosphoSitePlus. To better exhibit the relations between PTMs and diseases, we classified the PDAs into 6 classes, including U/D (Up-regulation/down-regulation of PTM levels), P/A (Presence/absence of PTMs) and C/N (Creation/disruption of PTM sites by mutations). We provided detailed annotations for each PDA event, and carefully annotated disease-associated proteins by integrating the knowledge from 101 additional resources that covered 13 aspects, including disease-associated information, variation and mutation, protein-protein interaction, protein functional annotation, DNA & RNA element, protein structure, chemical-target relation, mRNA expression, protein expression/proteomics, subcellular localization, biological pathway annotation, functional domain annotation, and physicochemical property. The PTMD 2.0 serves as a resource for further elucidating the molecular mechanisms underlying disease pathology. more details >>>

  Tp53 (Homo sapiens)