Uniprot AC Entrez ID Gene Name Disease Cell Type PTM Type State Position PMID P22681 867 CBL CBL2 RNF55 Rasopathy Ubiquitination N K7 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S15 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation C S17 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S22 P22681 867 CBL CBL2 RNF55 Hepatocellular carcinoma Ubiquitination N K58 P22681 867 CBL CBL2 RNF55 Rasopathy Ubiquitination N K58 P22681 867 CBL CBL2 RNF55 Rasopathy Ubiquitination N K74 P22681 867 CBL CBL2 RNF55 Breast invasive carcinoma Ubiquitination N K105 P22681 867 CBL CBL2 RNF55 Rasopathy Ubiquitination N K105 P22681 867 CBL CBL2 RNF55 Skin cutaneous melanoma Ubiquitination N K105 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N T126 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N Y141 P22681 867 CBL CBL2 RNF55 Cervical squamous cell carcinoma and endocervical adenocarcinoma Ubiquitination N K183 P22681 867 CBL CBL2 RNF55 Cervical squamous cell carcinoma and endocervical adenocarcinoma Acetylation N K197 P22681 867 CBL CBL2 RNF55 Rasopathy Acetylation N K197 P22681 867 CBL CBL2 RNF55 Head and neck squamous cell carcinoma Ubiquitination N K203 P22681 867 CBL CBL2 RNF55 Juvenile myelomonocytic leukemia Phosphorylation N T364 P22681 867 CBL CBL2 RNF55 Juvenile myelomonocytic leukemia Phosphorylation N Y368 P22681 867 CBL CBL2 RNF55 Noonan syndrome Phosphorylation N Y368 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N Y368 P22681 867 CBL CBL2 RNF55 Juvenile myelomonocytic leukemia Phosphorylation N Y371 P22681 867 CBL CBL2 RNF55 Malignant glioma Phosphorylation N Y371 P22681 867 CBL CBL2 RNF55 Noonan syndrome Phosphorylation N Y371 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N Y371 P22681 867 CBL CBL2 RNF55 Adrenocortical carcinoma Ubiquitination N K424 P22681 867 CBL CBL2 RNF55 Glioblastoma Ubiquitination N K424 P22681 867 CBL CBL2 RNF55 Juvenile myelomonocytic leukemia Ubiquitination N K424 P22681 867 CBL CBL2 RNF55 Rasopathy Ubiquitination N K424 P22681 867 CBL CBL2 RNF55 Skin cutaneous melanoma Ubiquitination N K424 P22681 867 CBL CBL2 RNF55 Bladder urothelial carcinoma Phosphorylation N S439 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S439 P22681 867 CBL CBL2 RNF55 Bladder urothelial carcinoma Phosphorylation N S441 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S441 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S452 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N Y455 P22681 867 CBL CBL2 RNF55 Hepatocellular carcinoma Phosphorylation N S483 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S483 P22681 867 CBL CBL2 RNF55 Skin cutaneous melanoma Phosphorylation N S483 P22681 867 CBL CBL2 RNF55 Hepatocellular carcinoma Phosphorylation N S486 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S486 P22681 867 CBL CBL2 RNF55 Skin cutaneous melanoma Phosphorylation N S486 P22681 867 CBL CBL2 RNF55 Pancreatic cancer Phosphorylation N S492 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S492 P22681 867 CBL CBL2 RNF55 Rasopathy Ubiquitination N K521 P22681 867 CBL CBL2 RNF55 Uterine corpus endometrial carcinoma Ubiquitination N K521 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N Y552 P22681 867 CBL CBL2 RNF55 Uterine corpus endometrial carcinoma Phosphorylation N Y552 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N T568 P22681 867 CBL CBL2 RNF55 Rasopathy Ubiquitination N K577 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S583 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S584 P22681 867 CBL CBL2 RNF55 Prostate adenocarcinoma Phosphorylation N S589 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S589 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation C S619 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S619 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S623 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S642 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N T645 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S652 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S667 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S668 P22681 867 CBL CBL2 RNF55 Skin cutaneous melanoma Phosphorylation N S668 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S669 P22681 867 CBL CBL2 RNF55 Skin cutaneous melanoma Phosphorylation N S669 P22681 867 CBL CBL2 RNF55 Uterine cancer Phosphorylation N S669 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N Y674 P22681 867 CBL CBL2 RNF55 Skin cutaneous melanoma Phosphorylation N Y674 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S675 P22681 867 CBL CBL2 RNF55 Skin cutaneous melanoma Phosphorylation N S675 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N Y700 P22681 867 CBL CBL2 RNF55 Thyroid carcinoma Phosphorylation N Y700 P22681 867 CBL CBL2 RNF55 Bladder urothelial carcinoma Phosphorylation N S714 P22681 867 CBL CBL2 RNF55 Kidney renal clear cell carcinoma Phosphorylation N S714 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S714 P22681 867 CBL CBL2 RNF55 Renal cell carcinoma Phosphorylation N S714 P22681 867 CBL CBL2 RNF55 Lung cancer Phosphorylation N Y731 P22681 867 CBL CBL2 RNF55 Malignant glioma Phosphorylation N Y731 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N Y731 P22681 867 CBL CBL2 RNF55 Stomach adenocarcinoma Phosphorylation N Y731 P22681 867 CBL CBL2 RNF55 Esophageal adenocarcinoma Phosphorylation N S767 P22681 867 CBL CBL2 RNF55 Head and neck squamous cell carcinoma Phosphorylation N S767 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S767 P22681 867 CBL CBL2 RNF55 Stomach adenocarcinoma Phosphorylation N S767 P22681 867 CBL CBL2 RNF55 Esophageal adenocarcinoma Phosphorylation N Y774 P22681 867 CBL CBL2 RNF55 Hepatocellular carcinoma Phosphorylation N Y774 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N Y774 P22681 867 CBL CBL2 RNF55 Bladder urothelial carcinoma Phosphorylation N S791 P22681 867 CBL CBL2 RNF55 Lung adenocarcinoma Phosphorylation N S791 P22681 867 CBL CBL2 RNF55 Prostate adenocarcinoma Phosphorylation N S791 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S791 P22681 867 CBL CBL2 RNF55 Bladder urothelial carcinoma Phosphorylation N S804 P22681 867 CBL CBL2 RNF55 Lung adenocarcinoma Phosphorylation N S804 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S804 P22681 867 CBL CBL2 RNF55 Kidney renal clear cell carcinoma Phosphorylation N S833 P22681 867 CBL CBL2 RNF55 Noonan syndrome Phosphorylation N S833 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S833 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S866 P22681 867 CBL CBL2 RNF55 Lung adenocarcinoma Phosphorylation N S900 P22681 867 CBL CBL2 RNF55 Rasopathy Phosphorylation N S900 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Acetylation N T2 Q06124 5781 PTPN11 PTP2C SHPTP2 Leukemia Phosphorylation N T59 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Phosphorylation N T59 Q06124 5781 PTPN11 PTP2C SHPTP2 Colon adenocarcinoma Phosphorylation N Y62 Q06124 5781 PTPN11 PTP2C SHPTP2 Glioblastoma Phosphorylation N Y62 Q06124 5781 PTPN11 PTP2C SHPTP2 Glioblastoma multiforme Phosphorylation N Y62 Q06124 5781 PTPN11 PTP2C SHPTP2 Juvenile myelomonocytic leukemia Phosphorylation N Y62 Q06124 5781 PTPN11 PTP2C SHPTP2 Leukemia Phosphorylation N Y62 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Phosphorylation N Y62 Q06124 5781 PTPN11 PTP2C SHPTP2 Rasopathy Phosphorylation N Y62 Q06124 5781 PTPN11 PTP2C SHPTP2 Colon adenocarcinoma Phosphorylation N Y63 Q06124 5781 PTPN11 PTP2C SHPTP2 Glioblastoma Phosphorylation N Y63 Q06124 5781 PTPN11 PTP2C SHPTP2 Glioblastoma multiforme Phosphorylation N Y63 Q06124 5781 PTPN11 PTP2C SHPTP2 Juvenile myelomonocytic leukemia Phosphorylation N Y63 Q06124 5781 PTPN11 PTP2C SHPTP2 Leukemia Phosphorylation N Y63 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Phosphorylation N Y63 Q06124 5781 PTPN11 PTP2C SHPTP2 Rasopathy Phosphorylation N Y63 Q06124 5781 PTPN11 PTP2C SHPTP2 Acute myeloid leukemia Phosphorylation N Y66 Q06124 5781 PTPN11 PTP2C SHPTP2 Brain lower grade glioma Phosphorylation N Y66 Q06124 5781 PTPN11 PTP2C SHPTP2 Colon adenocarcinoma Phosphorylation N Y66 Q06124 5781 PTPN11 PTP2C SHPTP2 Glioblastoma Phosphorylation N Y66 Q06124 5781 PTPN11 PTP2C SHPTP2 Glioblastoma multiforme Phosphorylation N Y66 Q06124 5781 PTPN11 PTP2C SHPTP2 Juvenile myelomonocytic leukemia Phosphorylation N Y66 Q06124 5781 PTPN11 PTP2C SHPTP2 Leukemia Phosphorylation N Y66 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Phosphorylation N Y66 Q06124 5781 PTPN11 PTP2C SHPTP2 Rasopathy Phosphorylation N Y66 Q06124 5781 PTPN11 PTP2C SHPTP2 Acute myeloid leukemia Phosphorylation N T73 Q06124 5781 PTPN11 PTP2C SHPTP2 Leukemia Phosphorylation N T73 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Phosphorylation N T73 Q06124 5781 PTPN11 PTP2C SHPTP2 Leukemia Phosphorylation N Y80 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Phosphorylation N Y80 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Phosphorylation N S142 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Acetylation N K198 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Ubiquitination N K260 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Phosphorylation N Y263 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Phosphorylation N S264 Q06124 5781 PTPN11 PTP2C SHPTP2 LEOPARD syndrome Acetylation N K274 Q06124 5781 PTPN11 PTP2C SHPTP2 LEOPARD syndrome Acetylation N K276 Q06124 5781 PTPN11 PTP2C SHPTP2 Glioblastoma multiforme Phosphorylation N Y279 Q06124 5781 PTPN11 PTP2C SHPTP2 Hepatocellular carcinoma Phosphorylation N Y279 Q06124 5781 PTPN11 PTP2C SHPTP2 LEOPARD syndrome Phosphorylation N Y279 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Phosphorylation N Y279 Q06124 5781 PTPN11 PTP2C SHPTP2 Rasopathy Phosphorylation N Y279 Q06124 5781 PTPN11 PTP2C SHPTP2 Glioblastoma multiforme Acetylation N K280 Q06124 5781 PTPN11 PTP2C SHPTP2 Hepatocellular carcinoma Acetylation N K280 Q06124 5781 PTPN11 PTP2C SHPTP2 LEOPARD syndrome Acetylation N K280 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Acetylation N K280 Q06124 5781 PTPN11 PTP2C SHPTP2 Rasopathy Acetylation N K280 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Phosphorylation N Y304 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Phosphorylation N T411 Q06124 5781 PTPN11 PTP2C SHPTP2 LEOPARD syndrome Phosphorylation N S460 Q06124 5781 PTPN11 PTP2C SHPTP2 LEOPARD syndrome Phosphorylation N T466 Q06124 5781 PTPN11 PTP2C SHPTP2 LEOPARD syndrome Phosphorylation N Y511 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Phosphorylation N Y511 Q06124 5781 PTPN11 PTP2C SHPTP2 LEOPARD syndrome Phosphorylation N Y515 Q06124 5781 PTPN11 PTP2C SHPTP2 Rasopathy Phosphorylation N Y542 Q06124 5781 PTPN11 PTP2C SHPTP2 Lung adenocarcinoma Phosphorylation N S558 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Phosphorylation N S558 Q06124 5781 PTPN11 PTP2C SHPTP2 Rasopathy Phosphorylation N S558 Q06124 5781 PTPN11 PTP2C SHPTP2 Uterine corpus endometrial carcinoma Phosphorylation N S558 Q06124 5781 PTPN11 PTP2C SHPTP2 Noonan syndrome Phosphorylation N T564 Q06124 5781 PTPN11 PTP2C SHPTP2 Arrhythmogenic right ventricular cardiomyopathy Phosphorylation N S576 Q06124 5781 PTPN11 PTP2C SHPTP2 Hepatocellular carcinoma Phosphorylation N S576 Q06124 5781 PTPN11 PTP2C SHPTP2 Hiatal hernia Phosphorylation N S576 Q06124 5781 PTPN11 PTP2C SHPTP2 Rasopathy Phosphorylation N S576 Q06124 5781 PTPN11 PTP2C SHPTP2 Hepatocellular carcinoma Phosphorylation N Y580 Q06124 5781 PTPN11 PTP2C SHPTP2 Hiatal hernia Phosphorylation N Y580 P22681 867 CBL CBL2 RNF55 Acute myeloid leukemia tumor tissue Dephosphorylation U Y371 36206490 Q06124 5781 PTPN11 PTP2C SHPTP2 Colorectal cancer CRC tissues Neddylation D K358 36626230 Q06124 5781 PTPN11 PTP2C SHPTP2 Colorectal cancer CRC tissues Neddylation D K364 36626230 Q06124 5781 PTPN11 PTP2C SHPTP2 Heart failure HEK293T cells Threonine phosphorylation P T73 25802336 Q06124 5781 PTPN11 PTP2C SHPTP2 Colorectal cancer CRC tissues Deneddylation U K358 36626230 Q06124 5781 PTPN11 PTP2C SHPTP2 Colorectal cancer CRC tissues Deneddylation U K364 36626230 Q06124 5781 PTPN11 PTP2C SHPTP2 Prostate cancer/carcinoma/adenocarcinoma tumor tissue Tyrosine phosphorylation U Y584 22307624 P22681 867 CBL CBL2 RNF55 Cancer Phosphorylation P 10891544 P22681 867 CBL CBL2 RNF55 Acute myeloid leukemia/acute myelogenous leukemia Tyrosine phosphorylation N Y371 20622007 Q06124 5781 PTPN11 PTP2C SHPTP2 Heart failure Serine phosphorylation P S189 25802336 Q06124 5781 PTPN11 PTP2C SHPTP2 Lymphoma Tyrosine phosphorylation U Y584 17483340