Uniprot AC Entrez ID Gene Name Disease Cell Type PTM Type State Position PMID P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N T8 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S52 P18206 7414 VCL Uterine corpus endometrial carcinoma Phosphorylation N S52 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K59 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K71 P18206 7414 VCL Hypertrophic cardiomyopathy Ubiquitination N K71 P18206 7414 VCL Melanoma Phosphorylation N S97 P18206 7414 VCL Cardiomyopathy Acetylation N K173 P18206 7414 VCL Dilated cardiomyopathy Acetylation N K173 P18206 7414 VCL Malignant glioma Acetylation N K173 P18206 7414 VCL Cardiomyopathy Phosphorylation C S207 P18206 7414 VCL Brain lower grade glioma Phosphorylation N S207 P18206 7414 VCL Brain lower grade glioma Ubiquitination N K216 P18206 7414 VCL Cardiomyopathy Ubiquitination N K216 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K216 P18206 7414 VCL Brain lower grade glioma Ubiquitination N K219 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K219 P18206 7414 VCL Breast invasive carcinoma Ubiquitination N K228 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K228 P18206 7414 VCL Skin cutaneous melanoma Ubiquitination N K228 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S252 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S260 P18206 7414 VCL Familial hypertrophic cardiomyopathy Phosphorylation N S272 P18206 7414 VCL Lung adenocarcinoma Phosphorylation N S272 P18206 7414 VCL Familial hypertrophic cardiomyopathy Phosphorylation N S275 P18206 7414 VCL Hepatocellular carcinoma Phosphorylation N S275 P18206 7414 VCL Lung adenocarcinoma Phosphorylation N S275 P18206 7414 VCL Hepatocellular carcinoma Acetylation N K276 P18206 7414 VCL Lung adenocarcinoma Acetylation N K276 P18206 7414 VCL Familial hypertrophic cardiomyopathy Ubiquitination N K276 P18206 7414 VCL Familial hypertrophic cardiomyopathy Ubiquitination N K281 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S288 P18206 7414 VCL Hepatocellular carcinoma Phosphorylation N S288 P18206 7414 VCL Hypertrophic cardiomyopathy Phosphorylation N S288 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S290 P18206 7414 VCL Hypertrophic cardiomyopathy Phosphorylation N S290 P18206 7414 VCL Uterine corpus endometrial carcinoma Ubiquitination N K308 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K316 P18206 7414 VCL Uterine corpus endometrial carcinoma Ubiquitination N K316 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N T324 P18206 7414 VCL Cardiomyopathy Phosphorylation N S345 P18206 7414 VCL Colon adenocarcinoma Phosphorylation N S345 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S345 P18206 7414 VCL Cardiomyopathy Phosphorylation N S346 P18206 7414 VCL Colon adenocarcinoma Phosphorylation N S346 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S346 P18206 7414 VCL Stomach cancer Phosphorylation N S346 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S357 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K366 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N T378 P18206 7414 VCL Bladder urothelial carcinoma Phosphorylation N S380 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S380 P18206 7414 VCL Bladder urothelial carcinoma Phosphorylation N S383 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S383 P18206 7414 VCL Bladder urothelial carcinoma Ubiquitination N K386 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K386 P18206 7414 VCL Bladder urothelial carcinoma Ubiquitination N K387 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K387 P18206 7414 VCL Dilated cardiomyopathy Methylation N R409 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K426 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation C S434 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S434 P18206 7414 VCL Hypertrophic cardiomyopathy Phosphorylation N S434 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S439 P18206 7414 VCL Hypertrophic cardiomyopathy Phosphorylation N S439 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N T442 P18206 7414 VCL Hypertrophic cardiomyopathy Phosphorylation N T442 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S443 P18206 7414 VCL Hypertrophic cardiomyopathy Phosphorylation N S443 P18206 7414 VCL Dilated cardiomyopathy Acetylation N K444 P18206 7414 VCL Hypertrophic cardiomyopathy Acetylation N K444 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K444 P18206 7414 VCL Hypertrophic cardiomyopathy Ubiquitination N K444 P18206 7414 VCL Cardiovascular phenotype Ubiquitination N K464 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K464 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K476 P18206 7414 VCL Pancreatic adenocarcinoma Ubiquitination N K476 P18206 7414 VCL Stomach adenocarcinoma Ubiquitination N K476 P18206 7414 VCL Dilated cardiomyopathy Acetylation N K496 P18206 7414 VCL Hepatocellular carcinoma Acetylation N K496 P18206 7414 VCL Lung squamous cell carcinoma Acetylation N K496 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N T508 P18206 7414 VCL Dilated cardiomyopathy Methylation N R512 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N Y537 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K544 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S566 P18206 7414 VCL Lung squamous cell carcinoma Phosphorylation N S566 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S574 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S579 P18206 7414 VCL Head and neck squamous cell carcinoma Phosphorylation N S579 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K581 P18206 7414 VCL Head and neck squamous cell carcinoma Ubiquitination N K581 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K584 P18206 7414 VCL Head and neck squamous cell carcinoma Ubiquitination N K584 P18206 7414 VCL Cardiomyopathy Phosphorylation N S596 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S596 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation C S600 P18206 7414 VCL Cardiomyopathy Phosphorylation N S600 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S600 P18206 7414 VCL Cardiomyopathy Phosphorylation N T604 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N T604 P18206 7414 VCL Cardiovascular phenotype Phosphorylation N T614 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N T614 P18206 7414 VCL Head and neck squamous cell carcinoma Phosphorylation N T614 P18206 7414 VCL Cardiovascular phenotype Methylation N R622 P18206 7414 VCL Dilated cardiomyopathy Methylation N R622 P18206 7414 VCL Head and neck squamous cell carcinoma Methylation N R622 P18206 7414 VCL Lung adenocarcinoma Methylation N R622 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S637 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K639 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N T643 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K655 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N T657 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S664 P18206 7414 VCL Kidney renal clear cell carcinoma Phosphorylation N S664 P18206 7414 VCL Lung adenocarcinoma Phosphorylation N S664 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K666 P18206 7414 VCL Kidney renal clear cell carcinoma Ubiquitination N K666 P18206 7414 VCL Lung adenocarcinoma Ubiquitination N K666 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N T672 P18206 7414 VCL Kidney renal clear cell carcinoma Phosphorylation N T672 P18206 7414 VCL Lung adenocarcinoma Phosphorylation N T672 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S677 P18206 7414 VCL Bladder urothelial carcinoma Phosphorylation N Y692 P18206 7414 VCL Dilated cardiomyopathy Acetylation N K699 P18206 7414 VCL Ovarian serous cystadenocarcinoma Acetylation N K699 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K699 P18206 7414 VCL Ovarian serous cystadenocarcinoma Ubiquitination N K699 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K708 P18206 7414 VCL Ovarian serous cystadenocarcinoma Ubiquitination N K708 P18206 7414 VCL Cardiovascular phenotype Phosphorylation N T719 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N T719 P18206 7414 VCL Cardiovascular phenotype Ubiquitination N K720 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K720 P18206 7414 VCL Cardiovascular phenotype Phosphorylation N S721 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S721 P18206 7414 VCL Cardiovascular phenotype Phosphorylation N S726 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S726 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K731 P18206 7414 VCL Uterine corpus endometrial carcinoma Ubiquitination N K731 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S755 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K768 P18206 7414 VCL Breast invasive carcinoma Ubiquitination N K778 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K778 P18206 7414 VCL Breast invasive carcinoma Ubiquitination N K784 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K784 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation C S787 P18206 7414 VCL Breast invasive carcinoma Phosphorylation N S787 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S787 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K792 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S795 P18206 7414 VCL Melanoma Phosphorylation N S795 P18206 7414 VCL Blastoma Phosphorylation N S809 P18206 7414 VCL Cardiomyopathy Phosphorylation N S809 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S809 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K815 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S816 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S820 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N Y822 P18206 7414 VCL Uterine cancer Phosphorylation N Y822 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K862 P18206 7414 VCL Cardiovascular phenotype Phosphorylation N S972 P18206 7414 VCL Colon adenocarcinoma Phosphorylation N S972 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S972 P18206 7414 VCL Uterine corpus endometrial carcinoma Phosphorylation N S972 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S981 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S982 P18206 7414 VCL Bladder urothelial carcinoma Ubiquitination N K983 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K983 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S1002 P18206 7414 VCL Stomach adenocarcinoma Ubiquitination N K1020 P18206 7414 VCL Dilated cardiomyopathy Ubiquitination N K1070 P18206 7414 VCL Uterine corpus endometrial carcinoma Ubiquitination N K1070 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S1080 P18206 7414 VCL Head and neck squamous cell carcinoma Phosphorylation N S1080 P18206 7414 VCL Uterine corpus endometrial carcinoma Phosphorylation N S1080 P18206 7414 VCL Kidney renal papillary cell carcinoma Phosphorylation N S1101 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N S1113 P18206 7414 VCL Head and neck squamous cell carcinoma Phosphorylation N S1113 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N T1123 P18206 7414 VCL Hepatocellular carcinoma Phosphorylation N T1123 P18206 7414 VCL Wolff-Parkinson-White pattern Phosphorylation N T1123 P18206 7414 VCL Dilated cardiomyopathy Phosphorylation N T1130 P18206 7414 VCL Wolff-Parkinson-White pattern Phosphorylation N T1130 P18206 7414 VCL Prostate cancer Phosphorylation N Y1133 P18206 7414 VCL Wolff-Parkinson-White pattern Phosphorylation N Y1133 Q96EB6 23411 SIRT1 SIR2L1 Thyroid carcinoma Phosphorylation N S14 Q96EB6 23411 SIRT1 SIR2L1 Skin cancer Phosphorylation N S27 Q96EB6 23411 SIRT1 SIR2L1 Stomach cancer Phosphorylation N S27 Q96EB6 23411 SIRT1 SIR2L1 Transitional cell carcinoma Phosphorylation N S47 Q96EB6 23411 SIRT1 SIR2L1 Bladder urothelial carcinoma Phosphorylation N S159 Q96EB6 23411 SIRT1 SIR2L1 Urinary bladder cancer Phosphorylation N S159 Q96EB6 23411 SIRT1 SIR2L1 Bladder urothelial carcinoma Phosphorylation N S162 Q96EB6 23411 SIRT1 SIR2L1 Adrenocortical carcinoma Phosphorylation N Y280 Q96EB6 23411 SIRT1 SIR2L1 Lung adenocarcinoma Phosphorylation N Y301 Q96EB6 23411 SIRT1 SIR2L1 Stomach adenocarcinoma Ubiquitination N K314 Q96EB6 23411 SIRT1 SIR2L1 Stomach adenocarcinoma Ubiquitination N K328 Q96EB6 23411 SIRT1 SIR2L1 Prostate adenocarcinoma Phosphorylation N T344 Q96EB6 23411 SIRT1 SIR2L1 Liver cancer S-Nitrosylation N C395 Q96EB6 23411 SIRT1 SIR2L1 Colorectal cancer S-Nitrosylation N C398 Q96EB6 23411 SIRT1 SIR2L1 Brain lower grade glioma Phosphorylation N Y428 Q96EB6 23411 SIRT1 SIR2L1 Skin cutaneous melanoma Ubiquitination N K499 Q96EB6 23411 SIRT1 SIR2L1 Pancreatic adenocarcinoma Ubiquitination N K506 Q96EB6 23411 SIRT1 SIR2L1 Hepatocellular carcinoma Ubiquitination N K513 Q96EB6 23411 SIRT1 SIR2L1 Pancreatic adenocarcinoma Ubiquitination N K513 Q96EB6 23411 SIRT1 SIR2L1 Lung adenocarcinoma Phosphorylation N T544 Q96EB6 23411 SIRT1 SIR2L1 Lung adenocarcinoma Phosphorylation N S545 Q96EB6 23411 SIRT1 SIR2L1 Head and neck squamous cell carcinoma Phosphorylation N T554 Q96EB6 23411 SIRT1 SIR2L1 Lung adenocarcinoma Phosphorylation N T554 Q96EB6 23411 SIRT1 SIR2L1 Head and neck squamous cell carcinoma Ubiquitination N K561 Q96EB6 23411 SIRT1 SIR2L1 Head and neck squamous cell carcinoma Phosphorylation N S562 Q96EB6 23411 SIRT1 SIR2L1 Bladder urothelial carcinoma Ubiquitination N K610 Q96EB6 23411 SIRT1 SIR2L1 Esophageal adenocarcinoma Ubiquitination N K610 Q96EB6 23411 SIRT1 SIR2L1 Bladder urothelial carcinoma Phosphorylation N S615 Q96EB6 23411 SIRT1 SIR2L1 Breast adenocarcinoma Phosphorylation N S615 Q96EB6 23411 SIRT1 SIR2L1 Breast invasive carcinoma Phosphorylation N S615 Q96EB6 23411 SIRT1 SIR2L1 Esophageal adenocarcinoma Phosphorylation N S615 Q96EB6 23411 SIRT1 SIR2L1 Bladder urothelial carcinoma Phosphorylation N T619 Q96EB6 23411 SIRT1 SIR2L1 Breast adenocarcinoma Phosphorylation N T619 Q96EB6 23411 SIRT1 SIR2L1 Breast invasive carcinoma Phosphorylation N T619 Q96EB6 23411 SIRT1 SIR2L1 Esophageal adenocarcinoma Phosphorylation N T619 Q96EB6 23411 SIRT1 SIR2L1 Bladder urothelial carcinoma Methylation N K622 Q96EB6 23411 SIRT1 SIR2L1 Breast adenocarcinoma Methylation N K622 Q96EB6 23411 SIRT1 SIR2L1 Breast invasive carcinoma Methylation N K622 Q96EB6 23411 SIRT1 SIR2L1 Esophageal adenocarcinoma Methylation N K622 Q96EB6 23411 SIRT1 SIR2L1 Breast invasive carcinoma Phosphorylation N S682 Q96EB6 23411 SIRT1 SIR2L1 Invasive lobular carcinoma Phosphorylation N S682 Q96EB6 23411 SIRT1 SIR2L1 Breast invasive carcinoma Phosphorylation N T719 Q96EB6 23411 SIRT1 SIR2L1 Renal cell carcinoma Phosphorylation N T719 Q96EB6 23411 SIRT1 SIR2L1 Colorectal cancer tumor tissue Ubiquitination A 32361710 Q96EB6 23411 SIRT1 SIR2L1 Colon cancer colon cancer cell line Serine phosphorylation U S27 34826187 Q96EB6 23411 SIRT1 SIR2L1 Hepatocellular carcinoma HCC tissues Serine phosphorylation U S47 34188177 Q96EB6 23411 SIRT1 SIR2L1 Colon cancer colon tumor tissues Deacetylation U K610 37530744 P18206 7414 VCL Atherogenesis Serine phosphorylation P S721 36380599 Q96EB6 23411 SIRT1 SIR2L1 Atherosclerosis Serine phosphorylation A S27 23754392 Q96EB6 23411 SIRT1 SIR2L1 Atherosclerosis Serine phosphorylation A S47 23754392 Q96EB6 23411 SIRT1 SIR2L1 Thoracic aortic aneurysm Our novel findings strongly suggest a causal role of Glutathionylation of SirT1 in the pathogenesis of TAA. Glutathionylation U 37288573 P18206 7414 VCL Leukemia Phosphorylation P 3130982 Q96EB6 23411 SIRT1 SIR2L1 Atherogenesis Sulfhydration D 29343087 Q96EB6 23411 SIRT1 SIR2L1 Diabetic nephropathy Sulfhydration D 33279869 Q96EB6 23411 SIRT1 SIR2L1 Parkinson's disease Ubiquitination U 29571747